Synthesis of 3-alkyl naphthalenes as novel estrogen receptor ligands

A novel series of 3-alkyl naphthalenes and their activity against estrogen receptor are reported. A series of estrogen receptor ligands based on a 3-alkyl naphthalene scaffold was synthesized using an intramolecular enolate-alkyne cycloaromatization as the key step. Several of these compounds bearin...

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Veröffentlicht in:	Bioorganic & medicinal chemistry 2008-09, Vol.18 (18), p.5075-5077
Hauptverfasser:	Fang, Jing, Akwabi-Ameyaw, Adwoa, Britton, Jonathan E., Katamreddy, Subba R., Navas, Frank, Miller, Aaron B., Williams, Shawn P., Gray, David W., Orband-Miller, Lisa A., Shearin, Jean, Heyer, Dennis
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES BASIC BIOLOGICAL SCIENCES Biological and medical sciences Combinatorial Chemistry Techniques ER binding Estrogen Receptor alpha - metabolism Estrogen Receptor beta - metabolism Estrogen receptor ligands Estrogen Receptor Modulators - metabolism ESTROGENS Female Hormones. Endocrine system Humans LIGANDS Medical sciences Molecular Structure NAPHTHALENE Naphthalenes - chemical synthesis Naphthalenes - chemistry Naphthalenes - pharmacology Pharmacology. Drug treatments RECEPTORS Receptors, Estrogen - agonists Selective Estrogen Receptor Modulators - metabolism Structure-Activity Relationship SYNTHESIS
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