X-ray crystal structure of the fibrinolysis inhibitor [alpha][subscript 2]-antiplasmin

The serpin alpha(2)-antiplasmin (SERPINF2) is the principal inhibitor of plasmin and inhibits fibrinolysis. Accordingly, alpha(2)-antiplasmin deficiency in humans results in uncontrolled fibrinolysis and a bleeding disorder. alpha(2)-antiplasmin is an unusual serpin, in that it contains extensive N-...

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Veröffentlicht in:	Blood 2008-12, Vol.111 ((4) ; 02, 2008)
Hauptverfasser:	Law, Ruby H.P., Sofian, Trifina, Kan, Wan-Ting, Horvath, Anita J., Hitchen, Corinne R., Langendorf, Christopher G., Buckle, Ashley M., Whisstock, James C., Coughlin, Paul B.
Format:	Artikel
Sprache:	eng
Schlagworte:	BODY CRYSTAL STRUCTURE FIBRIN FIBRINOLYSIN FIBRINOLYSIS HUMAN POPULATIONS INTERACTIONS MATERIALS SCIENCE
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