Microsecond acquisition of heterogeneous structure in the folding of a TIM barrel protein

The earliest kinetic folding events for (βα)₈ barrels reflect the appearance of off-pathway intermediates. Continuous-flow microchannel mixing methods interfaced to small-angle x-ray scattering (SAXS), circular dichroism (CD), time-resolved Förster resonant energy transfer (trFRET), and time-resolve...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2008-09, Vol.105 (36), p.13367-13372
Hauptverfasser:	Wu, Ying, Kondrashkina, Elena, Kayatekin, Can, Matthews, C. Robert, Bilsel, Osman
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES ANISOTROPY BASIC BIOLOGICAL SCIENCES Biochemistry Biological Sciences Crystallography, X-Ray DICHROISM DISTRIBUTION Energy ENERGY TRANSFER FLUORESCENCE FREE ENERGY KINETICS Models, Molecular MONITORS Photons Protein Folding Protein refolding Protein Structure, Secondary Protein Structure, Tertiary PROTEINS SCATTERING Spectrum Analysis Thermodynamics Time Factors TIME RESOLUTION Topology Triose-Phosphate Isomerase - chemistry Triose-Phosphate Isomerase - metabolism Tryptophan Synthase - chemistry Tryptophan Synthase - metabolism
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