Substituted tetrahydroquinolines as potent allosteric inhibitors of reverse transcriptase and its key mutants

Non-nucleoside reverse transcriptase inhibitors (NNRTIs) are key elements of multidrug regimens, called HAART (Highly Active Antiretroviral Therapy), that are used to treat HIV-1 infections. Elucidation of the structure–activity relationships of the thiocarbamate moiety of the previous published lea...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2009-09, Vol.19 (17), p.5119-5123
Hauptverfasser:	Su, Dai-Shi, Lim, John J., Tinney, Elizabeth, Wan, Bang-Lin, Young, Mary Beth, Anderson, Kenneth D., Rudd, Deanne, Munshi, Vandna, Bahnck, Carolyn, Felock, Peter J., Lu, Meiqing, Lai, Ming-Tain, Touch, Sinoeun, Moyer, Gregory, DiStefano, Daniel J., Flynn, Jessica A., Liang, Yuexia, Sanchez, Rosa, Prasad, Sridhar, Yan, Youwei, Perlow-Poehnelt, Rebecca, Torrent, Maricel, Miller, Mike, Vacca, Joe P., Williams, Theresa M., Anthony, Neville J.
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS VIRUS Allosteric Site Anti-HIV Agents - chemical synthesis Anti-HIV Agents - chemistry Anti-HIV Agents - pharmacology Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral agents BASIC BIOLOGICAL SCIENCES Binding Sites Biological and medical sciences Crystal structure Crystallography, X-Ray ENZYME INHIBITORS GENERAL AND MISCELLANEOUS//MATHEMATICS, COMPUTING, AND INFORMATION SCIENCE HIV Reverse Transcriptase - antagonists & inhibitors HIV Reverse Transcriptase - metabolism Human immunodeficiency virus 1 Medical sciences Molecular Conformation Molecular modeling Mutant Proteins - antagonists & inhibitors Mutant Proteins - metabolism Mutant virus MUTANTS MUTATIONS Non-nucleoside reverse transcriptase inhibitor (NNRTI) PHARMACOLOGY Pharmacology. Drug treatments QUINOLINES Quinolines - chemical synthesis Quinolines - chemistry Quinolines - pharmacology Reverse Transcriptase Inhibitors - chemical synthesis Reverse Transcriptase Inhibitors - chemistry Reverse Transcriptase Inhibitors - pharmacology SAR Structure-Activity Relationship STRUCTURE-ACTIVITY RELATIONSHIPS SYNTHESIS Tetrahydroquinoline THERAPY Thiocarbamates - chemistry Thiocarbamates - pharmacology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!