Rational design of an organometallic glutathione transferase inhibitor
A hybrid organic-inorganic (organometallic) inhibitor was designed to target glutathione transferases. The metal center is used to direct protein binding, while the organic moiety acts as the active-site inhibitor. The mechanism of inhibition was studied using a range of biophysical and biochemical...
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| Veröffentlicht in: | Angewandte Chemie (International ed.) 2010-08, Vol.48 ((21) ; 2009) |
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| container_issue | (21) ; 2009 |
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| container_title | Angewandte Chemie (International ed.) |
| container_volume | 48 |
| creator | Ang, W.H. Parker, L.J. De Luca, A. Juillerat-Jeanneret, L. Morton, C.J. LoBello, M. Parker, M.W. Dyson, P.J. |
| description | A hybrid organic-inorganic (organometallic) inhibitor was designed to target glutathione transferases. The metal center is used to direct protein binding, while the organic moiety acts as the active-site inhibitor. The mechanism of inhibition was studied using a range of biophysical and biochemical methods. |
| format | Article |
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| identifier | ISSN: 1433-7851 |
| ispartof | Angewandte Chemie (International ed.), 2010-08, Vol.48 ((21) ; 2009) |
| issn | 1433-7851 1521-3773 |
| language | eng |
| recordid | cdi_osti_scitechconnect_1006135 |
| source | Wiley Online Library Journals Frontfile Complete |
| subjects | BASIC BIOLOGICAL SCIENCES BIOLOGY CHEMISTRY DESIGN GENERAL AND MISCELLANEOUS//MATHEMATICS, COMPUTING, AND INFORMATION SCIENCE GLUTATHIONE PROTEINS TARGETS TRANSFERASES |
| title | Rational design of an organometallic glutathione transferase inhibitor |
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