Rational design of an organometallic glutathione transferase inhibitor

Rational design of an organometallic glutathione transferase inhibitor

A hybrid organic-inorganic (organometallic) inhibitor was designed to target glutathione transferases. The metal center is used to direct protein binding, while the organic moiety acts as the active-site inhibitor. The mechanism of inhibition was studied using a range of biophysical and biochemical...

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Veröffentlicht in:Angewandte Chemie (International ed.) 2010-08, Vol.48 ((21) ; 2009)
Hauptverfasser: Ang, W.H., Parker, L.J., De Luca, A., Juillerat-Jeanneret, L., Morton, C.J., LoBello, M., Parker, M.W., Dyson, P.J.
Format: Artikel
Sprache:eng
Schlagworte:
BASIC BIOLOGICAL SCIENCES
BIOLOGY
CHEMISTRY
DESIGN
GENERAL AND MISCELLANEOUS//MATHEMATICS, COMPUTING, AND INFORMATION SCIENCE
GLUTATHIONE
PROTEINS
TARGETS
TRANSFERASES
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Zusammenfassung:A hybrid organic-inorganic (organometallic) inhibitor was designed to target glutathione transferases. The metal center is used to direct protein binding, while the organic moiety acts as the active-site inhibitor. The mechanism of inhibition was studied using a range of biophysical and biochemical methods.
ISSN:1433-7851
1521-3773