Crystal structure of dimeric cardiac L-type calcium channel regulatory domains bridged by Ca[superscript 2+]·calmodulins

Voltage-dependent calcium channels (Ca(V)) open in response to changes in membrane potential, but their activity is modulated by Ca(2+) binding to calmodulin (CaM). Structural studies of this family of channels have focused on CaM bound to the IQ motif; however, the minimal differences between struc...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2009-11, Vol.106 ((13) ; 03, 2009)
Hauptverfasser:	Fallon, Jennifer L., Baker, Mariah R., Xiong, Liangwen, Loy, Ryan E., Yang, Guojun, Dirksen, Robert T., Hamilton, Susan L., Quiocho, Florante A.
Format:	Artikel
Sprache:	eng
Schlagworte:	CALCIUM CALMODULIN COMPUTER-AIDED MANUFACTURING CRYSTAL STRUCTURE DIMERS GENE MUTATIONS INACTIVATION MATERIALS SCIENCE MEMBRANES MIXTURES REGULATIONS
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!