Cellular Functions and X-ray Structure of Anthrolysin O, a Cholesterol-dependent Cytolysin Secreted by Bacillus anthracis

Anthrolysin O (ALO) is a pore-forming, cholesterol-dependent cytolysin (CDC) secreted by Bacillus anthracis, the etiologic agent for anthrax. Growing evidence suggests the involvement of ALO in anthrax pathogenesis. Here, we show that the apical application of ALO decreases the barrier function of h...

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Veröffentlicht in:	The Journal of biological chemistry 2009-05, Vol.284 (21), p.14645-14656
Hauptverfasser:	Bourdeau, Raymond W., Malito, Enrico, Chenal, Alexandre, Bishop, Brian L., Musch, Mark W., Villereal, Mitch L., Chang, Eugene B., Mosser, Elise M., Rest, Richard F., Tang, Wei-Jen
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence BACILLUS Bacillus anthracis Bacillus anthracis - cytology Bacillus anthracis - metabolism Bacterial Proteins - chemistry Bacterial Proteins - metabolism Bacterial Toxins - chemistry Bacterial Toxins - metabolism Bacteriocins - chemistry Bacteriocins - metabolism Biochemistry, Molecular Biology Caco-2 Cells CALCIUM Calcium - metabolism Cholesterol - metabolism CRYSTAL STRUCTURE Crystallography, X-Ray DIMERIZATION ELEMENTS Epithelial Cells - cytology Epithelial Cells - drug effects Epithelial Cells - metabolism FUNCTIONS Hemolysin Proteins - chemistry Hemolysin Proteins - metabolism HUMAN POPULATIONS Humans Intestines - cytology Intracellular Space - drug effects Intracellular Space - metabolism Ionomycin - pharmacology Life Sciences LIGHT SCATTERING MATERIALS SCIENCE Membrane Glycoproteins - chemistry Membrane Glycoproteins - metabolism Membrane Proteins - metabolism Models, Molecular Molecular Sequence Data Occludin PATHOGENESIS Perforin - chemistry Perforin - metabolism Permeability - drug effects Protein Binding - drug effects Protein Multimerization Protein Structure, Quaternary Protein Structure, Secondary Protein Structure, Tertiary PROTEINS Solubility - drug effects Tight Junctions - drug effects Tight Junctions - metabolism ULTRACENTRIFUGATION
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