Structure and Function of the Glycopeptide N-methyltransferase MtfA, a Tool for the Biosynthesis of Modified Glycopeptide Antibiotics

There is a considerable interest in the modification of existing antibiotics to generate new antimicrobials. Glycopeptide antibiotics (GPAs) are effective against serious Gram-positive bacterial pathogens including methicillin-resistant Staphylococcus aureus. However, resistance to these antibiotics...

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Veröffentlicht in:	Chemistry & biology 2009-04, Vol.16 (4), p.401-410
Hauptverfasser:	Shi, Rong, Lamb, Sherry S., Zakeri, Bijan, Proteau, Ariane, Cui, Qizhi, Sulea, Traian, Matte, Allan, Wright, Gerard D., Cygler, Miroslaw
Format:	Artikel
Sprache:	eng
Schlagworte:	Actinomycetales - enzymology Adenosine - analogs & derivatives Adenosine - chemistry Adenosine - metabolism Amycolatopsis orientalis Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - metabolism ANTIBIOTICS ANTIMICROBIAL AGENTS Bacterial Proteins - chemistry Bacterial Proteins - genetics Bacterial Proteins - metabolism BIOSYNTHESIS Catalytic Domain CHEMBIO CRYSTAL STRUCTURE Crystallography, X-Ray IN VITRO IN VIVO MATERIALS SCIENCE Methyltransferases - chemistry Methyltransferases - genetics Methyltransferases - metabolism Models, Molecular MODIFICATIONS MOLECULAR DYNAMICS METHOD MUTAGENESIS PATHOGENS Point Mutation Protein Binding Protein Multimerization S-Adenosylhomocysteine - chemistry S-Adenosylhomocysteine - metabolism S-Adenosylmethionine - chemistry S-Adenosylmethionine - metabolism STAPHYLOCOCCUS Staphylococcus aureus Teicoplanin - metabolism
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