Conformational switch triggered by [alpha]-ketoglutarate in a halogenase of curacin A biosynthesis

The CurA halogenase (Hal) catalyzes a cryptic chlorination leading to cyclopropane ring formation in the synthesis of the natural product curacin A. Hal belongs to a family of enzymes that use ..., ... and α-ketoglutarate (αKG) to perform a variety of halogenation reactions in natural product biosyn...

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