Xylitol Production by Kluyveromyces marxianus 36907-FMEL1 at High Temperature was Considerably Increased through the Optimization of Agitation Conditions

Recently, we isolated the mutant Kluyveromyces marxianus 36907-FMEL1, which demonstrated improved xylose reductase activity as compared to the parental strain, K. marxianus ATCC 36907. Effects of agitation conditions on xylitol production were verified using a bioreactor system. Under an agitation speed of 400 rpm, K. marxianus 36907-FMEL1 exhibited the highest xylitol yield (0.57 g/g) and productivity (0.64 g·l-1·h-1) at 30℃. When the fermentation temperature was increased to 40℃, interestingly, xylitol yield and productivity were found to be increased to 21% (0.64 g/g) and 58% (0.90 g·l-1·h-1), respectively, under the optimized agitation conditions. KCI Citation Count: 1