Anti-obesity Effect of Komulkosiraegi [Gracilaria vermiculophylla (Ohmi) Papenfuss] Extract in 3T3-L1 Cells

The ingestion of edible seaweed has long been believed to be beneficial to human health due to its numerous biological actions. In the present study, the ethyl acetate fraction of a komulkosiraegi [Gracilaria vermiculophylla (Ohmi) Papenfuss] ethanol extract (GEFr) was found to potently inhibit adip...

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Veröffentlicht in:	Food science and biotechnology 2012, 21(1), , pp.83-89
Hauptverfasser:	Kim, H.M., Jeju National University, Jeju, Republic of Korea, Kang, S.I., Jeju National University, Jeju, Republic of Korea, Shin, H.S., Jeju National University, Jeju, Republic of Korea, Ko, H.C., Jeju National University, Jeju, Republic of Korea, Hong, Y.S., Jeju National University, Jeju, Republic of Korea, Kang, S.W., Jeju National University, Jeju, Republic of Korea, Yoon, S.A., Jeju National University, Jeju, Republic of Korea, Kim, J.H., Jeju National University, Jeju, Republic of Korea, Kim, S.J., Jeju National University, Jeju, Republic of Korea
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipocytes adipogenesis AMP-activated protein kinase anti-adipogenic effect CCAAT/enhancer-binding protein Chemistry Chemistry and Materials Science Ethanol Ethyl acetate Fatty acid-binding protein Food Science Gracilaria vermiculophylla Lipid metabolism Lipolysis Liver LKB1 protein mRNA Nutrition Obesity OVERWEIGHT Peroxisome proliferator-activated receptors Preadipocytes Reactive oxygen species Research Article Seaweeds SOBREPESO SURPOIDS 식품과학
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Zusammenfassung:	The ingestion of edible seaweed has long been believed to be beneficial to human health due to its numerous biological actions. In the present study, the ethyl acetate fraction of a komulkosiraegi [Gracilaria vermiculophylla (Ohmi) Papenfuss] ethanol extract (GEFr) was found to potently inhibit adipogenesis of 3T3-L1 preadipocytes, decreasing triglycerol accumulation and the expression of peroxisome proliferator-activated receptor γ (PPARγ), members of the CCAAT/enhancer-binding protein (C/EBP) family, and fatty acid binding protein 2 (aP2). In mature adipocytes, GEFr was found to significantly activate AMP-activated protein kinase (AMPK) by activating liver kinase B1 (LKB1) and stimulating intracellular reactive oxygen species generation. The mRNA levels of genes involved in lipid catabolism were up-regulated. Also, GEFr increased lipolysis in a dose-dependent manner. Taken together, these results suggest that GEFr has potential for use in therapies designed to improve obesity.
ISSN:	1226-7708 2092-6456
DOI:	10.1007/s10068-012-0010-8