method to select for mutator DNA polymerase δs in Saccharomyces cerevisiae

Proofreading DNA polymerases share common short peptide motifs that bind Mg2+ in the exonuclease active center; however, hydrolysis rates are not the same for all of the enzymes, which indicates that there are functional and likely structural differences outside of the conserved residues. Since stru...

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Veröffentlicht in:	Genome 2006-04, Vol.49 (4), p.403-410
Hauptverfasser:	Murphy, K, Darmawan, H, Schultz, A, Da Silva, E.F, Reha-Krantz, L.J
Format:	Artikel
Sprache:	eng
Schlagworte:	DNA polymerases DNA replication DNA-directed DNA polymerase mutants mutator DNA polymerase mutator mutants phenotype Saccharomyces cerevisiae yeasts
Online-Zugang:	Volltext
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