Atherosclerosis and acute arterial thrombosis in rabbits: a model using balloon desendothelization without dietary intervention
Content Partner: Directory of Open Access Journals. Acute thrombosis can be induced in rabbits by a triggering protocol using Russell's viper venom and histamine given after 8 months of a 1% cholesterol diet and balloon desendothelization. In the present study, we tested the hypothesis that aor...
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| creator | Picon P.D Gonçalves S.C Wainstein M.V Costa A.F Mengarda C.V Machado R.P Berlim G.L Edelweiss M Edelweiss M.I Ribeiro J.P |
| description | Content Partner: Directory of Open Access Journals. Acute thrombosis can be induced in rabbits by a triggering protocol using Russell's viper venom and histamine given after 8 months of a 1% cholesterol diet and balloon desendothelization. In the present study, we tested the hypothesis that aortic desendothelization performed 4 months before the triggering protocol without a high cholesterol diet is a highly effective and less expensive way of producing arterial atherosclerosis and thrombosis. Nineteen male New Zealand white rabbits on a normal diet were studied. The control group (N = 9) received no intervention during the 4-month observation period, while the other group (N = 10) was submitted to aortic balloon desendothelization using a 4F Fogarty catheter. At the end of this period, all animals were killed 48 h after receiving the first dose of the triggering treatment. Eight of 10 rabbits (80%) in the balloon-trauma group presented platelet-rich arterial thrombosis while none of the animals in the control group had thrombus formation (P |
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Acute thrombosis can be induced in rabbits by a triggering protocol using Russell's viper venom and histamine given after 8 months of a 1% cholesterol diet and balloon desendothelization. In the present study, we tested the hypothesis that aortic desendothelization performed 4 months before the triggering protocol without a high cholesterol diet is a highly effective and less expensive way of producing arterial atherosclerosis and thrombosis. Nineteen male New Zealand white rabbits on a normal diet were studied. The control group (N = 9) received no intervention during the 4-month observation period, while the other group (N = 10) was submitted to aortic balloon desendothelization using a 4F Fogarty catheter. At the end of this period, all animals were killed 48 h after receiving the first dose of the triggering treatment. Eight of 10 rabbits (80%) in the balloon-trauma group presented platelet-rich arterial thrombosis while none of the animals in the control group had thrombus formation (P<0.01). Thus, this model, using balloon desendothelization without dietary manipulation, induces arterial atherosclerosis and thrombosis and may provide possibilities to test new therapeutic approaches</description><language>eng</language><publisher>Associação Brasileira de Divulgação Científica</publisher><creationdate>1997-01</creationdate><rights>Some rights reserved</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>776,25572</link.rule.ids><linktorsrc>$$Uhttp://api.digitalnz.org/records/35189362/source$$EView_record_in_DigitalNZ$$FView_record_in_$$GDigitalNZ$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>Picon P.D</creatorcontrib><creatorcontrib>Gonçalves S.C</creatorcontrib><creatorcontrib>Wainstein M.V</creatorcontrib><creatorcontrib>Costa A.F</creatorcontrib><creatorcontrib>Mengarda C.V</creatorcontrib><creatorcontrib>Machado R.P</creatorcontrib><creatorcontrib>Berlim G.L</creatorcontrib><creatorcontrib>Edelweiss M</creatorcontrib><creatorcontrib>Edelweiss M.I</creatorcontrib><creatorcontrib>Ribeiro J.P</creatorcontrib><title>Atherosclerosis and acute arterial thrombosis in rabbits: a model using balloon desendothelization without dietary intervention</title><description>Content Partner: Directory of Open Access Journals. Acute thrombosis can be induced in rabbits by a triggering protocol using Russell's viper venom and histamine given after 8 months of a 1% cholesterol diet and balloon desendothelization. In the present study, we tested the hypothesis that aortic desendothelization performed 4 months before the triggering protocol without a high cholesterol diet is a highly effective and less expensive way of producing arterial atherosclerosis and thrombosis. Nineteen male New Zealand white rabbits on a normal diet were studied. The control group (N = 9) received no intervention during the 4-month observation period, while the other group (N = 10) was submitted to aortic balloon desendothelization using a 4F Fogarty catheter. At the end of this period, all animals were killed 48 h after receiving the first dose of the triggering treatment. Eight of 10 rabbits (80%) in the balloon-trauma group presented platelet-rich arterial thrombosis while none of the animals in the control group had thrombus formation (P<0.01). 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Acute thrombosis can be induced in rabbits by a triggering protocol using Russell's viper venom and histamine given after 8 months of a 1% cholesterol diet and balloon desendothelization. In the present study, we tested the hypothesis that aortic desendothelization performed 4 months before the triggering protocol without a high cholesterol diet is a highly effective and less expensive way of producing arterial atherosclerosis and thrombosis. Nineteen male New Zealand white rabbits on a normal diet were studied. The control group (N = 9) received no intervention during the 4-month observation period, while the other group (N = 10) was submitted to aortic balloon desendothelization using a 4F Fogarty catheter. At the end of this period, all animals were killed 48 h after receiving the first dose of the triggering treatment. Eight of 10 rabbits (80%) in the balloon-trauma group presented platelet-rich arterial thrombosis while none of the animals in the control group had thrombus formation (P<0.01). Thus, this model, using balloon desendothelization without dietary manipulation, induces arterial atherosclerosis and thrombosis and may provide possibilities to test new therapeutic approaches</abstract><pub>Associação Brasileira de Divulgação Científica</pub><oa>free_for_read</oa></addata></record> |
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| title | Atherosclerosis and acute arterial thrombosis in rabbits: a model using balloon desendothelization without dietary intervention |
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