Post-Spaceflight Orthostatic Hypotension Occurs Mostly in Women and is Predicted by Low Vascular Resistance

Post-Spaceflight Orthostatic Hypotension Occurs Mostly in Women and is Predicted by Low Vascular Resistance

About 20% of astronauts suffer post-spaceflight presyncope, but the underlying etiology remains elusive. We studied responses to standing in 36 astronauts before and after spaceflight (5- 16 days). Individuals were separated into presyncopal women, presyncopal men, and non-presyncopal men based on t...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Waters, Wendy W., Ziegler, Michael G., Meck, Janice V.
Format: Report
Sprache:eng
Schlagworte:
Aerospace Medicine
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page
container_issue
container_start_page
container_title
container_volume
creator Waters, Wendy W.
Ziegler, Michael G.
Meck, Janice V.
description About 20% of astronauts suffer post-spaceflight presyncope, but the underlying etiology remains elusive. We studied responses to standing in 36 astronauts before and after spaceflight (5- 16 days). Individuals were separated into presyncopal women, presyncopal men, and non-presyncopal men based on their ability to stand for 10 min postflight. Preflight, presyncopal women and presyncopal men had low vascular resistance, with the women having the lowest. Postflight, women experienced significantly higher rates of presyncope (P
format Report
fullrecord <record><control><sourceid>nasa_CYI</sourceid><recordid>TN_cdi_nasa_ntrs_20100033503</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>20100033503</sourcerecordid><originalsourceid>FETCH-nasa_ntrs_201000335033</originalsourceid><addsrcrecordid>eNqFjDEKwkAQRdNYiHoDi7lAYDV4AlFSKAkqWsq4mZjBdTbsbJDc3i3sLT4P3oM_zV6115ife7TUOn52EaoQu-QwsoVy7H0kUfYClbVDUDim5kZggZt_kwBKA6xQB2rYRmrgMcLBf-CKageHAU6knO7E0jybtOiUFj_OsuV-d9mWuaDiXWLQ-9qsjDFFsUn7k78o6T0J</addsrcrecordid><sourcetype>Publisher</sourcetype><iscdi>true</iscdi><recordtype>report</recordtype></control><display><type>report</type><title>Post-Spaceflight Orthostatic Hypotension Occurs Mostly in Women and is Predicted by Low Vascular Resistance</title><source>NASA Technical Reports Server</source><creator>Waters, Wendy W. ; Ziegler, Michael G. ; Meck, Janice V.</creator><creatorcontrib>Waters, Wendy W. ; Ziegler, Michael G. ; Meck, Janice V.</creatorcontrib><description><![CDATA[About 20% of astronauts suffer post-spaceflight presyncope, but the underlying etiology remains elusive. We studied responses to standing in 36 astronauts before and after spaceflight (5- 16 days). Individuals were separated into presyncopal women, presyncopal men, and non-presyncopal men based on their ability to stand for 10 min postflight. Preflight, presyncopal women and presyncopal men had low vascular resistance, with the women having the lowest. Postflight, women experienced significantly higher rates of presyncope (P<0.01) and significantly greater losses of plasma volume than the men (P<0.05). Both presyncopal women and men had lower standing arterial pressure (P<=0.001) and vascular resistance (P<0.05), smaller increases in norepinephrine (P<=0.058) and greater increases in epinephrine (P<=0.058) than nonpresyncopal men. Both presyncopal groups had a strong dependence (P<=0.05) on plasma volume to maintain standing stroke volume. These findings suggest that postflight presyncope is ascribed to a combination of inherently low resistance responses, a strong dependence on volume status, and spaceflight-induced hypoadrenergic responses. In contrast, high vascular resistance and spaceflight-induced hyperadrenergic responses prevent presyncope.]]></description><language>eng</language><publisher>Johnson Space Center</publisher><subject>Aerospace Medicine</subject><creationdate>2001</creationdate><rights>Copyright Determination: PUBLIC_USE_PERMITTED</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>776,796,4476</link.rule.ids><linktorsrc>$$Uhttps://ntrs.nasa.gov/citations/20100033503$$EView_record_in_NASA$$FView_record_in_$$GNASA$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>Waters, Wendy W.</creatorcontrib><creatorcontrib>Ziegler, Michael G.</creatorcontrib><creatorcontrib>Meck, Janice V.</creatorcontrib><title>Post-Spaceflight Orthostatic Hypotension Occurs Mostly in Women and is Predicted by Low Vascular Resistance</title><description><![CDATA[About 20% of astronauts suffer post-spaceflight presyncope, but the underlying etiology remains elusive. We studied responses to standing in 36 astronauts before and after spaceflight (5- 16 days). Individuals were separated into presyncopal women, presyncopal men, and non-presyncopal men based on their ability to stand for 10 min postflight. Preflight, presyncopal women and presyncopal men had low vascular resistance, with the women having the lowest. Postflight, women experienced significantly higher rates of presyncope (P<0.01) and significantly greater losses of plasma volume than the men (P<0.05). Both presyncopal women and men had lower standing arterial pressure (P<=0.001) and vascular resistance (P<0.05), smaller increases in norepinephrine (P<=0.058) and greater increases in epinephrine (P<=0.058) than nonpresyncopal men. Both presyncopal groups had a strong dependence (P<=0.05) on plasma volume to maintain standing stroke volume. These findings suggest that postflight presyncope is ascribed to a combination of inherently low resistance responses, a strong dependence on volume status, and spaceflight-induced hypoadrenergic responses. In contrast, high vascular resistance and spaceflight-induced hyperadrenergic responses prevent presyncope.]]></description><subject>Aerospace Medicine</subject><fulltext>true</fulltext><rsrctype>report</rsrctype><creationdate>2001</creationdate><recordtype>report</recordtype><sourceid>CYI</sourceid><recordid>eNqFjDEKwkAQRdNYiHoDi7lAYDV4AlFSKAkqWsq4mZjBdTbsbJDc3i3sLT4P3oM_zV6115ife7TUOn52EaoQu-QwsoVy7H0kUfYClbVDUDim5kZggZt_kwBKA6xQB2rYRmrgMcLBf-CKageHAU6knO7E0jybtOiUFj_OsuV-d9mWuaDiXWLQ-9qsjDFFsUn7k78o6T0J</recordid><startdate>20010101</startdate><enddate>20010101</enddate><creator>Waters, Wendy W.</creator><creator>Ziegler, Michael G.</creator><creator>Meck, Janice V.</creator><scope>CYE</scope><scope>CYI</scope></search><sort><creationdate>20010101</creationdate><title>Post-Spaceflight Orthostatic Hypotension Occurs Mostly in Women and is Predicted by Low Vascular Resistance</title><author>Waters, Wendy W. ; Ziegler, Michael G. ; Meck, Janice V.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-nasa_ntrs_201000335033</frbrgroupid><rsrctype>reports</rsrctype><prefilter>reports</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Aerospace Medicine</topic><toplevel>online_resources</toplevel><creatorcontrib>Waters, Wendy W.</creatorcontrib><creatorcontrib>Ziegler, Michael G.</creatorcontrib><creatorcontrib>Meck, Janice V.</creatorcontrib><collection>NASA Scientific and Technical Information</collection><collection>NASA Technical Reports Server</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Waters, Wendy W.</au><au>Ziegler, Michael G.</au><au>Meck, Janice V.</au><format>book</format><genre>unknown</genre><ristype>RPRT</ristype><btitle>Post-Spaceflight Orthostatic Hypotension Occurs Mostly in Women and is Predicted by Low Vascular Resistance</btitle><date>2001-01-01</date><risdate>2001</risdate><abstract><![CDATA[About 20% of astronauts suffer post-spaceflight presyncope, but the underlying etiology remains elusive. We studied responses to standing in 36 astronauts before and after spaceflight (5- 16 days). Individuals were separated into presyncopal women, presyncopal men, and non-presyncopal men based on their ability to stand for 10 min postflight. Preflight, presyncopal women and presyncopal men had low vascular resistance, with the women having the lowest. Postflight, women experienced significantly higher rates of presyncope (P<0.01) and significantly greater losses of plasma volume than the men (P<0.05). Both presyncopal women and men had lower standing arterial pressure (P<=0.001) and vascular resistance (P<0.05), smaller increases in norepinephrine (P<=0.058) and greater increases in epinephrine (P<=0.058) than nonpresyncopal men. Both presyncopal groups had a strong dependence (P<=0.05) on plasma volume to maintain standing stroke volume. These findings suggest that postflight presyncope is ascribed to a combination of inherently low resistance responses, a strong dependence on volume status, and spaceflight-induced hypoadrenergic responses. In contrast, high vascular resistance and spaceflight-induced hyperadrenergic responses prevent presyncope.]]></abstract><cop>Johnson Space Center</cop><oa>free_for_read</oa></addata></record>
fulltext fulltext_linktorsrc
identifier
ispartof
issn
language eng
recordid cdi_nasa_ntrs_20100033503
source NASA Technical Reports Server
subjects Aerospace Medicine
title Post-Spaceflight Orthostatic Hypotension Occurs Mostly in Women and is Predicted by Low Vascular Resistance
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-27T21%3A11%3A17IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-nasa_CYI&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=unknown&rft.btitle=Post-Spaceflight%20Orthostatic%20Hypotension%20Occurs%20Mostly%20in%20Women%20and%20is%20Predicted%20by%20Low%20Vascular%20Resistance&rft.au=Waters,%20Wendy%20W.&rft.date=2001-01-01&rft_id=info:doi/&rft_dat=%3Cnasa_CYI%3E20100033503%3C/nasa_CYI%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true