Growth hormone/IGF-I and/or resistive exercise maintains myonuclear number in hindlimb unweighted muscles
David L. Allen 1 , Jon K. Linderman 2 , Roland R. Roy 3 , Richard E. Grindeland 2 , Venkat Mukku 4 , and V. Reggie Edgerton 1 , 3 1 Department of Physiological Science and 3 Brain Research Institute, University of California, Los Angeles, 90095-1527; 2 National Aeronautics and Space Administratio...
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| creator | Allen, David L Linderman, Jon K Roy, Roland R Grindeland, Richard E Mukku, Venkat Edgerton, V. Reggie |
| description | David L.
Allen 1 ,
Jon K.
Linderman 2 ,
Roland R.
Roy 3 ,
Richard E.
Grindeland 2 ,
Venkat
Mukku 4 , and
V. Reggie
Edgerton 1 , 3
1 Department of Physiological
Science and 3 Brain Research
Institute, University of California, Los Angeles, 90095-1527;
2 National Aeronautics and Space
Administration-Ames Research Center, Moffett Field, 94035-1000; and
4 Genentech Incorporated, South
San Francisco, California 94080
Received 6 January 1997; accepted in final form 15 July 1997.
Allen, David L., Jon K. Linderman, Roland R. Roy, Richard E. Grindeland, Venkat Mukku, and V. Reggie Edgerton. Growth hormone/IGF-I and/or resistive exercise maintains myonuclear
number in hindlimb unweighted muscles. J. Appl.
Physiol. 83(5): 1857-1861, 1997. In the present
study of rats, we examined the role, during 2 wk of
hindlimb suspension, of growth hormone/insulin-like growth factor I
(GH/IGF-I) administration and/or brief bouts of resistance exercise in ameliorating the loss of myonuclei in fibers of the soleus
muscle that express type I myosin heavy chain. Hindlimb suspension
resulted in a significant decrease in mean soleus wet weight that was
attenuated either by exercise alone or by exercise plus GH/IGF-I
treatment but was not attenuated by hormonal treatment alone. Both mean
myonuclear number and mean fiber cross-sectional area (CSA) of fibers
expressing type I myosin heavy chain decreased after 2 wk of suspension
compared with control (134 vs. 162 myonuclei/mm and 917 vs. 2,076 µm 2 , respectively). Neither
GH/IGF-I treatment nor exercise alone affected myonuclear number or
fiber CSA, but the combination of exercise and growth-factor treatment
attenuated the decrease in both variables. A significant correlation
was found between mean myonuclear number and mean CSA across all
groups. Thus GH/IGF-I administration and brief bouts of muscle loading
had an interactive effect in attenuating the loss of myonuclei induced
by chronic unloading.
atrophy; unloading; remodeling; plasticity; countermeasures
0161-7567/97 $5.00
Copyright © 1997 the American Physiological Society |
| doi_str_mv | 10.1152/jappl.1997.83.6.1857 |
| format | Article |
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Allen 1 ,
Jon K.
Linderman 2 ,
Roland R.
Roy 3 ,
Richard E.
Grindeland 2 ,
Venkat
Mukku 4 , and
V. Reggie
Edgerton 1 , 3
1 Department of Physiological
Science and 3 Brain Research
Institute, University of California, Los Angeles, 90095-1527;
2 National Aeronautics and Space
Administration-Ames Research Center, Moffett Field, 94035-1000; and
4 Genentech Incorporated, South
San Francisco, California 94080
Received 6 January 1997; accepted in final form 15 July 1997.
Allen, David L., Jon K. Linderman, Roland R. Roy, Richard E. Grindeland, Venkat Mukku, and V. Reggie Edgerton. Growth hormone/IGF-I and/or resistive exercise maintains myonuclear
number in hindlimb unweighted muscles. J. Appl.
Physiol. 83(5): 1857-1861, 1997. In the present
study of rats, we examined the role, during 2 wk of
hindlimb suspension, of growth hormone/insulin-like growth factor I
(GH/IGF-I) administration and/or brief bouts of resistance exercise in ameliorating the loss of myonuclei in fibers of the soleus
muscle that express type I myosin heavy chain. Hindlimb suspension
resulted in a significant decrease in mean soleus wet weight that was
attenuated either by exercise alone or by exercise plus GH/IGF-I
treatment but was not attenuated by hormonal treatment alone. Both mean
myonuclear number and mean fiber cross-sectional area (CSA) of fibers
expressing type I myosin heavy chain decreased after 2 wk of suspension
compared with control (134 vs. 162 myonuclei/mm and 917 vs. 2,076 µm 2 , respectively). Neither
GH/IGF-I treatment nor exercise alone affected myonuclear number or
fiber CSA, but the combination of exercise and growth-factor treatment
attenuated the decrease in both variables. A significant correlation
was found between mean myonuclear number and mean CSA across all
groups. Thus GH/IGF-I administration and brief bouts of muscle loading
had an interactive effect in attenuating the loss of myonuclei induced
by chronic unloading.
atrophy; unloading; remodeling; plasticity; countermeasures
0161-7567/97 $5.00
Copyright © 1997 the American Physiological Society</description><identifier>ISSN: 8750-7587</identifier><identifier>EISSN: 1522-1601</identifier><identifier>DOI: 10.1152/jappl.1997.83.6.1857</identifier><identifier>PMID: 9390955</identifier><identifier>CODEN: JAPHEV</identifier><language>eng</language><publisher>Legacy CDMS: Am Physiological Soc</publisher><subject>Aerospace Medicine ; Animals ; Biological and medical sciences ; Cell Count - drug effects ; Cell Nucleus - ultrastructure ; Cytoplasm - ultrastructure ; Electrophoresis, Polyacrylamide Gel ; Female ; Fundamental and applied biological sciences. Psychology ; Growth Hormone - pharmacology ; Hindlimb - physiology ; Hindlimb Suspension ; Insulin-Like Growth Factor I - pharmacology ; Microscopy, Confocal ; Muscle, Skeletal - cytology ; Muscle, Skeletal - drug effects ; Muscle, Skeletal - physiology ; Organ Size ; Physical Conditioning, Animal - physiology ; Rats ; Rats, Sprague-Dawley ; Recombinant Proteins - pharmacology ; Space life sciences ; Striated muscle. Tendons ; Vertebrates: osteoarticular system, musculoskeletal system</subject><ispartof>Journal of applied physiology (1985), 1997-12, Vol.83 (6), p.1857-1861</ispartof><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c496t-c5f61092e90f5226d5c1ab1c0ddbb51674d61a277bae4c505e36883b4e2e434e3</citedby><cites>FETCH-LOGICAL-c496t-c5f61092e90f5226d5c1ab1c0ddbb51674d61a277bae4c505e36883b4e2e434e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,3039,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2105998$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9390955$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Allen, David L</creatorcontrib><creatorcontrib>Linderman, Jon K</creatorcontrib><creatorcontrib>Roy, Roland R</creatorcontrib><creatorcontrib>Grindeland, Richard E</creatorcontrib><creatorcontrib>Mukku, Venkat</creatorcontrib><creatorcontrib>Edgerton, V. Reggie</creatorcontrib><title>Growth hormone/IGF-I and/or resistive exercise maintains myonuclear number in hindlimb unweighted muscles</title><title>Journal of applied physiology (1985)</title><addtitle>J Appl Physiol (1985)</addtitle><description>David L.
Allen 1 ,
Jon K.
Linderman 2 ,
Roland R.
Roy 3 ,
Richard E.
Grindeland 2 ,
Venkat
Mukku 4 , and
V. Reggie
Edgerton 1 , 3
1 Department of Physiological
Science and 3 Brain Research
Institute, University of California, Los Angeles, 90095-1527;
2 National Aeronautics and Space
Administration-Ames Research Center, Moffett Field, 94035-1000; and
4 Genentech Incorporated, South
San Francisco, California 94080
Received 6 January 1997; accepted in final form 15 July 1997.
Allen, David L., Jon K. Linderman, Roland R. Roy, Richard E. Grindeland, Venkat Mukku, and V. Reggie Edgerton. Growth hormone/IGF-I and/or resistive exercise maintains myonuclear
number in hindlimb unweighted muscles. J. Appl.
Physiol. 83(5): 1857-1861, 1997. In the present
study of rats, we examined the role, during 2 wk of
hindlimb suspension, of growth hormone/insulin-like growth factor I
(GH/IGF-I) administration and/or brief bouts of resistance exercise in ameliorating the loss of myonuclei in fibers of the soleus
muscle that express type I myosin heavy chain. Hindlimb suspension
resulted in a significant decrease in mean soleus wet weight that was
attenuated either by exercise alone or by exercise plus GH/IGF-I
treatment but was not attenuated by hormonal treatment alone. Both mean
myonuclear number and mean fiber cross-sectional area (CSA) of fibers
expressing type I myosin heavy chain decreased after 2 wk of suspension
compared with control (134 vs. 162 myonuclei/mm and 917 vs. 2,076 µm 2 , respectively). Neither
GH/IGF-I treatment nor exercise alone affected myonuclear number or
fiber CSA, but the combination of exercise and growth-factor treatment
attenuated the decrease in both variables. A significant correlation
was found between mean myonuclear number and mean CSA across all
groups. Thus GH/IGF-I administration and brief bouts of muscle loading
had an interactive effect in attenuating the loss of myonuclei induced
by chronic unloading.
atrophy; unloading; remodeling; plasticity; countermeasures
0161-7567/97 $5.00
Copyright © 1997 the American Physiological Society</description><subject>Aerospace Medicine</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cell Count - drug effects</subject><subject>Cell Nucleus - ultrastructure</subject><subject>Cytoplasm - ultrastructure</subject><subject>Electrophoresis, Polyacrylamide Gel</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Growth Hormone - pharmacology</subject><subject>Hindlimb - physiology</subject><subject>Hindlimb Suspension</subject><subject>Insulin-Like Growth Factor I - pharmacology</subject><subject>Microscopy, Confocal</subject><subject>Muscle, Skeletal - cytology</subject><subject>Muscle, Skeletal - drug effects</subject><subject>Muscle, Skeletal - physiology</subject><subject>Organ Size</subject><subject>Physical Conditioning, Animal - physiology</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Recombinant Proteins - pharmacology</subject><subject>Space life sciences</subject><subject>Striated muscle. Tendons</subject><subject>Vertebrates: osteoarticular system, musculoskeletal system</subject><issn>8750-7587</issn><issn>1522-1601</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>CYI</sourceid><sourceid>EIF</sourceid><recordid>eNp1kEGP1CAYhonRrOPqP1gTDsZ4aQcKlHI0G2ecZBMv65nQ9uuWDYUKrbPz722dySQePBAO7_N-fDwI3VGSUyqK7bMZR5dTpWResbzMaSXkK7RZoiKjJaGv0aaSgmRSVPItepfSMyGUc0Fv0I1iiighNsjuYzhOPe5DHIKH7WG_yw7Y-HYbIo6QbJrsb8DwArGxCfBgrJ-Wk_BwCn5uHJiI_TzUELH1uLe-dXao8eyPYJ_6CVo8zGnB0nv0pjMuwYfLfYt-7r493n_PHn7sD_dfH7KGq3LKGtGVlKgCFOmWn5StaKipaUPatq4FLSVvS2oKKWsDvBFEACuritUcCuCMA7tFn89zxxh-zZAmPdjUgHPGQ5iTloqXjPFqAfkZbGJIKUKnx2gHE0-aEr0a1n8N69Wwrpgu9Wp4qX28zJ_rAdpr6aJ0yT9dcpMa47po_GLuihWUCKXW1-_OmDfJaD_FpAtCOKGykIos8Zdz3C8WjzaCHvtTssGFp9O61z8L8f-ju9m5R3iZ1s61ose2Y38AzfiwkQ</recordid><startdate>19971201</startdate><enddate>19971201</enddate><creator>Allen, David L</creator><creator>Linderman, Jon K</creator><creator>Roy, Roland R</creator><creator>Grindeland, Richard E</creator><creator>Mukku, Venkat</creator><creator>Edgerton, V. Reggie</creator><general>Am Physiological Soc</general><general>American Physiological Society</general><scope>CYE</scope><scope>CYI</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19971201</creationdate><title>Growth hormone/IGF-I and/or resistive exercise maintains myonuclear number in hindlimb unweighted muscles</title><author>Allen, David L ; Linderman, Jon K ; Roy, Roland R ; Grindeland, Richard E ; Mukku, Venkat ; Edgerton, V. Reggie</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c496t-c5f61092e90f5226d5c1ab1c0ddbb51674d61a277bae4c505e36883b4e2e434e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Aerospace Medicine</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cell Count - drug effects</topic><topic>Cell Nucleus - ultrastructure</topic><topic>Cytoplasm - ultrastructure</topic><topic>Electrophoresis, Polyacrylamide Gel</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Growth Hormone - pharmacology</topic><topic>Hindlimb - physiology</topic><topic>Hindlimb Suspension</topic><topic>Insulin-Like Growth Factor I - pharmacology</topic><topic>Microscopy, Confocal</topic><topic>Muscle, Skeletal - cytology</topic><topic>Muscle, Skeletal - drug effects</topic><topic>Muscle, Skeletal - physiology</topic><topic>Organ Size</topic><topic>Physical Conditioning, Animal - physiology</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Recombinant Proteins - pharmacology</topic><topic>Space life sciences</topic><topic>Striated muscle. Tendons</topic><topic>Vertebrates: osteoarticular system, musculoskeletal system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Allen, David L</creatorcontrib><creatorcontrib>Linderman, Jon K</creatorcontrib><creatorcontrib>Roy, Roland R</creatorcontrib><creatorcontrib>Grindeland, Richard E</creatorcontrib><creatorcontrib>Mukku, Venkat</creatorcontrib><creatorcontrib>Edgerton, V. Reggie</creatorcontrib><collection>NASA Scientific and Technical Information</collection><collection>NASA Technical Reports Server</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of applied physiology (1985)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Allen, David L</au><au>Linderman, Jon K</au><au>Roy, Roland R</au><au>Grindeland, Richard E</au><au>Mukku, Venkat</au><au>Edgerton, V. Reggie</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Growth hormone/IGF-I and/or resistive exercise maintains myonuclear number in hindlimb unweighted muscles</atitle><jtitle>Journal of applied physiology (1985)</jtitle><addtitle>J Appl Physiol (1985)</addtitle><date>1997-12-01</date><risdate>1997</risdate><volume>83</volume><issue>6</issue><spage>1857</spage><epage>1861</epage><pages>1857-1861</pages><issn>8750-7587</issn><eissn>1522-1601</eissn><coden>JAPHEV</coden><abstract>David L.
Allen 1 ,
Jon K.
Linderman 2 ,
Roland R.
Roy 3 ,
Richard E.
Grindeland 2 ,
Venkat
Mukku 4 , and
V. Reggie
Edgerton 1 , 3
1 Department of Physiological
Science and 3 Brain Research
Institute, University of California, Los Angeles, 90095-1527;
2 National Aeronautics and Space
Administration-Ames Research Center, Moffett Field, 94035-1000; and
4 Genentech Incorporated, South
San Francisco, California 94080
Received 6 January 1997; accepted in final form 15 July 1997.
Allen, David L., Jon K. Linderman, Roland R. Roy, Richard E. Grindeland, Venkat Mukku, and V. Reggie Edgerton. Growth hormone/IGF-I and/or resistive exercise maintains myonuclear
number in hindlimb unweighted muscles. J. Appl.
Physiol. 83(5): 1857-1861, 1997. In the present
study of rats, we examined the role, during 2 wk of
hindlimb suspension, of growth hormone/insulin-like growth factor I
(GH/IGF-I) administration and/or brief bouts of resistance exercise in ameliorating the loss of myonuclei in fibers of the soleus
muscle that express type I myosin heavy chain. Hindlimb suspension
resulted in a significant decrease in mean soleus wet weight that was
attenuated either by exercise alone or by exercise plus GH/IGF-I
treatment but was not attenuated by hormonal treatment alone. Both mean
myonuclear number and mean fiber cross-sectional area (CSA) of fibers
expressing type I myosin heavy chain decreased after 2 wk of suspension
compared with control (134 vs. 162 myonuclei/mm and 917 vs. 2,076 µm 2 , respectively). Neither
GH/IGF-I treatment nor exercise alone affected myonuclear number or
fiber CSA, but the combination of exercise and growth-factor treatment
attenuated the decrease in both variables. A significant correlation
was found between mean myonuclear number and mean CSA across all
groups. Thus GH/IGF-I administration and brief bouts of muscle loading
had an interactive effect in attenuating the loss of myonuclei induced
by chronic unloading.
atrophy; unloading; remodeling; plasticity; countermeasures
0161-7567/97 $5.00
Copyright © 1997 the American Physiological Society</abstract><cop>Legacy CDMS</cop><pub>Am Physiological Soc</pub><pmid>9390955</pmid><doi>10.1152/jappl.1997.83.6.1857</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 8750-7587 |
| ispartof | Journal of applied physiology (1985), 1997-12, Vol.83 (6), p.1857-1861 |
| issn | 8750-7587 1522-1601 |
| language | eng |
| recordid | cdi_nasa_ntrs_20040172790 |
| source | MEDLINE; American Physiological Society Paid; NASA Technical Reports Server; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Aerospace Medicine Animals Biological and medical sciences Cell Count - drug effects Cell Nucleus - ultrastructure Cytoplasm - ultrastructure Electrophoresis, Polyacrylamide Gel Female Fundamental and applied biological sciences. Psychology Growth Hormone - pharmacology Hindlimb - physiology Hindlimb Suspension Insulin-Like Growth Factor I - pharmacology Microscopy, Confocal Muscle, Skeletal - cytology Muscle, Skeletal - drug effects Muscle, Skeletal - physiology Organ Size Physical Conditioning, Animal - physiology Rats Rats, Sprague-Dawley Recombinant Proteins - pharmacology Space life sciences Striated muscle. Tendons Vertebrates: osteoarticular system, musculoskeletal system |
| title | Growth hormone/IGF-I and/or resistive exercise maintains myonuclear number in hindlimb unweighted muscles |
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