Inhaled Molgramostim Therapy in Autoimmune Pulmonary Alveolar Proteinosis
Patients with autoimmune pulmonary alveolar proteinosis received inhaled molgramostim or matching placebo for 24 weeks. Patients receiving molgramostim had greater improvement in pulmonary gas transfer and alleviation of symptoms than those receiving placebo.
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| Veröffentlicht in: | The New England journal of medicine 2020-10, Vol.383 (17), p.1635-1644 |
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| container_title | The New England journal of medicine |
| container_volume | 383 |
| creator | Trapnell, Bruce C Inoue, Yoshikazu Bonella, Francesco Morgan, Cliff Jouneau, Stéphane Bendstrup, Elisabeth Campo, Ilaria Papiris, Spyros A Yamaguchi, Etsuro Cetinkaya, Erdogan Ilkovich, Mikhail M Kramer, Mordechai R Veltkamp, Marcel Kreuter, Michael Baba, Tomohisa Ganslandt, Cecilia Tarnow, Inge Waterer, Grant Jouhikainen, Taneli |
| description | Patients with autoimmune pulmonary alveolar proteinosis received inhaled molgramostim or matching placebo for 24 weeks. Patients receiving molgramostim had greater improvement in pulmonary gas transfer and alleviation of symptoms than those receiving placebo. |
| doi_str_mv | 10.1056/NEJMoa1913590 |
| format | Article |
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Patients receiving molgramostim had greater improvement in pulmonary gas transfer and alleviation of symptoms than those receiving placebo.</description><subject>Administration, Inhalation</subject><subject>Adult</subject><subject>Alveoli</subject><subject>Autoimmune Diseases - drug therapy</subject><subject>Autoimmune Diseases - physiopathology</subject><subject>Autoimmune Diseases - therapy</subject><subject>Biomarkers</subject><subject>Blood pressure</subject><subject>Bronchoalveolar Lavage</subject><subject>Colony-stimulating factor</subject><subject>Disease</subject><subject>Double-Blind Method</subject><subject>Drug Administration Schedule</subject><subject>Exercise Tolerance</subject><subject>FDA approval</subject><subject>Female</subject><subject>General & Internal Medicine</subject><subject>Granulocyte-macrophage colony-stimulating factor</subject><subject>Granulocyte-Macrophage Colony-Stimulating Factor - administration & dosage</subject><subject>Granulocyte-Macrophage Colony-Stimulating Factor - 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| subjects | Administration, Inhalation Adult Alveoli Autoimmune Diseases - drug therapy Autoimmune Diseases - physiopathology Autoimmune Diseases - therapy Biomarkers Blood pressure Bronchoalveolar Lavage Colony-stimulating factor Disease Double-Blind Method Drug Administration Schedule Exercise Tolerance FDA approval Female General & Internal Medicine Granulocyte-macrophage colony-stimulating factor Granulocyte-Macrophage Colony-Stimulating Factor - administration & dosage Granulocyte-Macrophage Colony-Stimulating Factor - adverse effects Health Status Humans Hypoxemia Inhalation Lavage Life Sciences Life Sciences & Biomedicine Male Medicine, General & Internal Middle Aged Oxygen - blood Pathogenesis Pulmonary Alveolar Proteinosis - drug therapy Pulmonary Alveolar Proteinosis - physiopathology Pulmonary Alveolar Proteinosis - therapy Pulmonary Gas Exchange Rare diseases Recombinant Proteins - administration & dosage Recombinant Proteins - adverse effects Science & Technology Sediments Statistical analysis Surfactants Walk Test |
| title | Inhaled Molgramostim Therapy in Autoimmune Pulmonary Alveolar Proteinosis |
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