The Effects of Minimally Invasive Periodontal Surgery on Bone Resorption and Angiogenesis

Purpose: Minimally invasive surgery (MIS) yields favorable clinical outcomes for periodontal regeneration therapy. However, there have been few reports on the histological analysis underlying these outcomes. In this study, we created periodontal defects to investigate two different surgical procedures by histological assessment in the early wound healing process. Results: On the experimental side, inflammatory cell infiltration disappeared earlier than on the control side. Tartrate-resistant acid phosphatase-positive cell counts for bone defects on postoperative days 3 and 5 were significantly lower on the experimental side. The number of blood vessels on postoperative days 3 and 5 was significantly larger on the experimental side. Conclusion: The results suggest that minimally invasive periodontal surgery can reduce the emergence of osteoclasts in the early postoperative period, enhance angiogenesis, and facilitate healing.