IL-12 and IL-18 synergistically induce the bactericidal activity of murine peritoneal cells against M. leprae

We examined the effect of IL-12 and IL-18 on bactericidal activities of mouse peritoneal cell (PC) against Mycobacterium leprae (M. leprae). We demonstrated that IL-12 and IL-18 synergistically induced the NO-dependent bactericidal activity of PC by stimulating Natural Killer (NK) cells and T-cells...

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Veröffentlicht in:	JAPANESE JOURNAL OF LEPROSY 2001, Vol.70(3), pp.113-119
Hauptverfasser:	Nomaguchi, Hiroko, Jahan, Nilufar, Mandal, Bhairab Chandra, Yogi, Yasuko, Kawatsu, Kunio, Yoshizawa, Yusuke, Okamura, Haruki, Makino, Masahiko
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals bactericidal activity Cells, Cultured Drug Synergism Female IL-12 IL-18 Interferon-gamma - metabolism Interleukin-12 - pharmacology Interleukin-12 - physiology Interleukin-18 - pharmacology Interleukin-18 - physiology Killer Cells, Natural - immunology Killer Cells, Natural - metabolism M. leprae Mice Mice, Inbred BALB C murine peritoneal cell Mycobacterium leprae - immunology Nitric Oxide - metabolism Peritoneal Cavity - cytology T-Lymphocytes - immunology T-Lymphocytes - metabolism
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Zusammenfassung:	We examined the effect of IL-12 and IL-18 on bactericidal activities of mouse peritoneal cell (PC) against Mycobacterium leprae (M. leprae). We demonstrated that IL-12 and IL-18 synergistically induced the NO-dependent bactericidal activity of PC by stimulating Natural Killer (NK) cells and T-cells through IFN-γ production. IL-12 and IL-18 induced host cell death through NK-cells and T-cells. Therefore, IL-12 and IL-18 play an important role on direct killing of intracellular M. leprae and on indirect killing of them through inducing host cell death.
ISSN:	1342-3681 1884-314X
DOI:	10.5025/hansen.70.113