4-2 Influence of Antithrobmbolitc Therapy on Microembolic Signals (MES) Detected by Serial Transcranial Doppler (TCD) in Acute Cerebral Infarction

Objective：To investigate the influence of autithrombotic therapy on microembolic signals (MES) detected in cerebral infarction patients. Subjects and Methods：Sixteen patients with acute-phase cerebral infarction showing MES (mean age：63±8 years). On admission. the MES number (number 20 ninutes) of the middle cerebral artery was determined with a TCD instrument (Multi -Dop X4). MES were defined as the signals with an intensity of 6 dB accompanied by harmonic sound (HS). Patients with MES were assigned to the argatrobau group (Group A) or the ozagrel Na group (Group O). The second TCD was performed after one week of treatment in Group A and after two weeks of treatment in Group O Results：(1) Argatroban group：There was no significant difference in MES number before (13.0±9.0) and after treatment (15.4±15.2). (2) Ozagrel Na group：The MES number decreased significantly after treatment with ozagrel Na (8.1±7.2) compared with before treatment (14.1±7.1)(p