Early Changes in Androgen Levels in Individuals with Spinal Cord Injury: A Longitudinal SwiSCI Study
Context Menopause has been associated with adverse cardiovascular disease (CVD) risk profile, yet it is unclear whether the changes in CVD risk factors differ by reproductive stage independently of underlying ageing trajectories. Design The CoLaus study is a prospective population-based cohort study...
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creator | Raguindin, Peter Francis Itodo, Oche Adam Wöllner, Jens Eriks-Hoogland, Inge Jordan, Xavier Hund-Georgiadis, Margret Muka, Taulant Pannek, Jürgen Stoyanov, Jivko Glisic, Marija |
description | Context Menopause has been associated with adverse cardiovascular disease (CVD) risk profile, yet it is unclear whether the changes in CVD risk factors differ by reproductive stage independently of underlying ageing trajectories. Design The CoLaus study is a prospective population-based cohort study in Lausanne, Switzerland. Patients We used data from women at baseline and follow-up (mean: 5.6 ± 0.5 years) from 2003 to 2012 who did not use hormone therapy. We classified women into (i) premenopausal, (ii) menopausal transition, (iii) early (≤5 years) and (iv) late (>5 years) postmenopausal by comparing their menstruation status at baseline and follow-up. Measurements We measured fasting lipids, glucose and cardiovascular inflammatory markers. We used repeated measures (linear mixed models) for longitudinal analysis, using premenopausal women as a reference category. We adjusted analyses for age, medications and lifestyle factors. Results We used the data from 1710 women aged 35–75 years. Longitudinal analysis showed that the changes in CVD risk factors were not different in the other three menopausal categories compared to premenopausal women. When age was used as a predictor variable and adjusted for menopause status, most CVD risk factors increased, while interleukin-6 and interleukin-1β decreased with advancing age. Conclusion The current study suggests that women have a worsening cardiovascular risk profile as they age, and although menopausal women may have higher levels of cardiovascular risk factors compared to premenopausal women at any given time, the 5-year changes in cardiovascular risk factors may not depend on the reproductive stage. |
doi_str_mv | 10.5281/zenodo.8123544 |
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Design The CoLaus study is a prospective population-based cohort study in Lausanne, Switzerland. Patients We used data from women at baseline and follow-up (mean: 5.6 ± 0.5 years) from 2003 to 2012 who did not use hormone therapy. We classified women into (i) premenopausal, (ii) menopausal transition, (iii) early (≤5 years) and (iv) late (>5 years) postmenopausal by comparing their menstruation status at baseline and follow-up. Measurements We measured fasting lipids, glucose and cardiovascular inflammatory markers. We used repeated measures (linear mixed models) for longitudinal analysis, using premenopausal women as a reference category. We adjusted analyses for age, medications and lifestyle factors. Results We used the data from 1710 women aged 35–75 years. Longitudinal analysis showed that the changes in CVD risk factors were not different in the other three menopausal categories compared to premenopausal women. When age was used as a predictor variable and adjusted for menopause status, most CVD risk factors increased, while interleukin-6 and interleukin-1β decreased with advancing age. Conclusion The current study suggests that women have a worsening cardiovascular risk profile as they age, and although menopausal women may have higher levels of cardiovascular risk factors compared to premenopausal women at any given time, the 5-year changes in cardiovascular risk factors may not depend on the reproductive stage.</description><identifier>DOI: 10.5281/zenodo.8123544</identifier><language>ger</language><publisher>Zenodo</publisher><subject>androgens ; dehydroepiandrosterone ; dehydroepiandrosterone sulfate ; rehabilitation ; sex hormone-binding globulin ; spinal cord injury ; testosterone</subject><creationdate>2022-11</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><orcidid>0000-0001-9716-4746</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>316,781,27865</link.rule.ids><linktorsrc>$$Uhttps://zenodo.org/record/8123544$$EView_record_in_LORY_(Lucerne_Open_Repository)$$FView_record_in_$$GLORY_(Lucerne_Open_Repository)$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>Raguindin, Peter Francis</creatorcontrib><creatorcontrib>Itodo, Oche Adam</creatorcontrib><creatorcontrib>Wöllner, Jens</creatorcontrib><creatorcontrib>Eriks-Hoogland, Inge</creatorcontrib><creatorcontrib>Jordan, Xavier</creatorcontrib><creatorcontrib>Hund-Georgiadis, Margret</creatorcontrib><creatorcontrib>Muka, Taulant</creatorcontrib><creatorcontrib>Pannek, Jürgen</creatorcontrib><creatorcontrib>Stoyanov, Jivko</creatorcontrib><creatorcontrib>Glisic, Marija</creatorcontrib><title>Early Changes in Androgen Levels in Individuals with Spinal Cord Injury: A Longitudinal SwiSCI Study</title><description>Context Menopause has been associated with adverse cardiovascular disease (CVD) risk profile, yet it is unclear whether the changes in CVD risk factors differ by reproductive stage independently of underlying ageing trajectories. Design The CoLaus study is a prospective population-based cohort study in Lausanne, Switzerland. Patients We used data from women at baseline and follow-up (mean: 5.6 ± 0.5 years) from 2003 to 2012 who did not use hormone therapy. We classified women into (i) premenopausal, (ii) menopausal transition, (iii) early (≤5 years) and (iv) late (>5 years) postmenopausal by comparing their menstruation status at baseline and follow-up. Measurements We measured fasting lipids, glucose and cardiovascular inflammatory markers. We used repeated measures (linear mixed models) for longitudinal analysis, using premenopausal women as a reference category. We adjusted analyses for age, medications and lifestyle factors. Results We used the data from 1710 women aged 35–75 years. Longitudinal analysis showed that the changes in CVD risk factors were not different in the other three menopausal categories compared to premenopausal women. When age was used as a predictor variable and adjusted for menopause status, most CVD risk factors increased, while interleukin-6 and interleukin-1β decreased with advancing age. Conclusion The current study suggests that women have a worsening cardiovascular risk profile as they age, and although menopausal women may have higher levels of cardiovascular risk factors compared to premenopausal women at any given time, the 5-year changes in cardiovascular risk factors may not depend on the reproductive stage.</description><subject>androgens</subject><subject>dehydroepiandrosterone</subject><subject>dehydroepiandrosterone sulfate</subject><subject>rehabilitation</subject><subject>sex hormone-binding globulin</subject><subject>spinal cord injury</subject><subject>testosterone</subject><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>LYEOE</sourceid><recordid>eNqFjj0LwjAURbM4iLq6Ce8PWO0XFLcSKha6xb0EEttIeJHYtKS_3lC6O13OPVy4hBzja5QnRXyZJRphoiJO0jzLtkRU3GoPtOfYyS8ohBKFNZ1EaOQo9VLVKNSohOMBJzX0wD4KuQZqrAjy7ay_QQmNwU4NTiyOTYrRGlhgvyebV9jKw5o7crpXT_o4azdLi6021rdj0q6v0n_-B6EMQXg</recordid><startdate>20221104</startdate><enddate>20221104</enddate><creator>Raguindin, Peter Francis</creator><creator>Itodo, Oche Adam</creator><creator>Wöllner, Jens</creator><creator>Eriks-Hoogland, Inge</creator><creator>Jordan, Xavier</creator><creator>Hund-Georgiadis, Margret</creator><creator>Muka, Taulant</creator><creator>Pannek, Jürgen</creator><creator>Stoyanov, Jivko</creator><creator>Glisic, Marija</creator><general>Zenodo</general><scope>LYEOE</scope><orcidid>https://orcid.org/0000-0001-9716-4746</orcidid></search><sort><creationdate>20221104</creationdate><title>Early Changes in Androgen Levels in Individuals with Spinal Cord Injury: A Longitudinal SwiSCI Study</title><author>Raguindin, Peter Francis ; Itodo, Oche Adam ; Wöllner, Jens ; Eriks-Hoogland, Inge ; Jordan, Xavier ; Hund-Georgiadis, Margret ; Muka, Taulant ; Pannek, Jürgen ; Stoyanov, Jivko ; Glisic, Marija</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-luzern_lory_v2_81235443</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>ger</language><creationdate>2022</creationdate><topic>androgens</topic><topic>dehydroepiandrosterone</topic><topic>dehydroepiandrosterone sulfate</topic><topic>rehabilitation</topic><topic>sex hormone-binding globulin</topic><topic>spinal cord injury</topic><topic>testosterone</topic><toplevel>online_resources</toplevel><creatorcontrib>Raguindin, Peter Francis</creatorcontrib><creatorcontrib>Itodo, Oche Adam</creatorcontrib><creatorcontrib>Wöllner, Jens</creatorcontrib><creatorcontrib>Eriks-Hoogland, Inge</creatorcontrib><creatorcontrib>Jordan, Xavier</creatorcontrib><creatorcontrib>Hund-Georgiadis, Margret</creatorcontrib><creatorcontrib>Muka, Taulant</creatorcontrib><creatorcontrib>Pannek, Jürgen</creatorcontrib><creatorcontrib>Stoyanov, Jivko</creatorcontrib><creatorcontrib>Glisic, Marija</creatorcontrib><collection>LORY (Lucerne Open Repository)</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Raguindin, Peter Francis</au><au>Itodo, Oche Adam</au><au>Wöllner, Jens</au><au>Eriks-Hoogland, Inge</au><au>Jordan, Xavier</au><au>Hund-Georgiadis, Margret</au><au>Muka, Taulant</au><au>Pannek, Jürgen</au><au>Stoyanov, Jivko</au><au>Glisic, Marija</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Early Changes in Androgen Levels in Individuals with Spinal Cord Injury: A Longitudinal SwiSCI Study</atitle><date>2022-11-04</date><risdate>2022</risdate><abstract>Context Menopause has been associated with adverse cardiovascular disease (CVD) risk profile, yet it is unclear whether the changes in CVD risk factors differ by reproductive stage independently of underlying ageing trajectories. Design The CoLaus study is a prospective population-based cohort study in Lausanne, Switzerland. Patients We used data from women at baseline and follow-up (mean: 5.6 ± 0.5 years) from 2003 to 2012 who did not use hormone therapy. We classified women into (i) premenopausal, (ii) menopausal transition, (iii) early (≤5 years) and (iv) late (>5 years) postmenopausal by comparing their menstruation status at baseline and follow-up. Measurements We measured fasting lipids, glucose and cardiovascular inflammatory markers. We used repeated measures (linear mixed models) for longitudinal analysis, using premenopausal women as a reference category. We adjusted analyses for age, medications and lifestyle factors. Results We used the data from 1710 women aged 35–75 years. Longitudinal analysis showed that the changes in CVD risk factors were not different in the other three menopausal categories compared to premenopausal women. When age was used as a predictor variable and adjusted for menopause status, most CVD risk factors increased, while interleukin-6 and interleukin-1β decreased with advancing age. Conclusion The current study suggests that women have a worsening cardiovascular risk profile as they age, and although menopausal women may have higher levels of cardiovascular risk factors compared to premenopausal women at any given time, the 5-year changes in cardiovascular risk factors may not depend on the reproductive stage.</abstract><pub>Zenodo</pub><doi>10.5281/zenodo.8123544</doi><orcidid>https://orcid.org/0000-0001-9716-4746</orcidid><oa>free_for_read</oa></addata></record> |
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subjects | androgens dehydroepiandrosterone dehydroepiandrosterone sulfate rehabilitation sex hormone-binding globulin spinal cord injury testosterone |
title | Early Changes in Androgen Levels in Individuals with Spinal Cord Injury: A Longitudinal SwiSCI Study |
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