Pharmacokinetics of First-Line Drugs in Children With Tuberculosis, Using World Health Organization-Recommended Weight Band Doses and Formulations

Pharmacokinetics of First-Line Drugs in Children With Tuberculosis, Using World Health Organization-Recommended Weight Band Doses and Formulations

BACKGROUND: Dispersible pediatric fixed-dose combination (FDC) tablets delivering higher doses of first-line antituberculosis drugs in World Health Organization-recommended weight bands were introduced in 2015. We report the first pharmacokinetic data for these FDC tablets in Zambian and South Afric...

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Veröffentlicht in:CLINICAL INFECTIOUS DISEASES 2021-08, Vol.74 (10), p.1767-1775
Hauptverfasser: Chabala, Chishala, Turkova, Anna, Hesseling, Anneke C, Zimba, Kevin M, van der Zalm, Marieke, Kapasa, Monica, Palmer, Megan, Chirehwa, Maxwell, Wiesner, Lubbe, Wobudeya, Eric, Kinikar, Aarti, Mave, Vidya, Hissar, Syed, Choo, Louise, LeBeau, Kristen, Mulenga, Veronica, Aarnoutse, Robb, Gibb, Diana, McIlleron, Helen
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Sprache:eng
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Zusammenfassung:BACKGROUND: Dispersible pediatric fixed-dose combination (FDC) tablets delivering higher doses of first-line antituberculosis drugs in World Health Organization-recommended weight bands were introduced in 2015. We report the first pharmacokinetic data for these FDC tablets in Zambian and South African children in the treatment-shortening SHINE trial. METHODS: Children weighing 4.0-7.9, 8.0-11.9, 12.0-15.9, or 16.0-24.9 kg received 1, 2, 3, or 4 tablets daily, respectively (rifampicin/isoniazid/pyrazinamide [75/50/150 mg], with or without 100 mg ethambutol, or rifampicin/isoniazid [75/50 mg]). Children 25.0-36.9 kg received doses recommended for adults 
ISSN:1058-4838
DOI:10.1093/cid/ciab725