How Arginine-Rich Domains Coordinate mRNA Maturation Events

Maturation of RNA is highly regulated from transcription to the post-transcriptional processing and localization to specific cellular compartments. The complexes that contribute to these events are in many cases well understood; however, many of the protein factors that coordinate and regulate these...

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Veröffentlicht in:RNA biology 2007-04, Vol.4 (2), p.69-75
Hauptverfasser: Godin, Katherine S., Varani, Gabriele
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Varani, Gabriele
description Maturation of RNA is highly regulated from transcription to the post-transcriptional processing and localization to specific cellular compartments. The complexes that contribute to these events are in many cases well understood; however, many of the protein factors that coordinate and regulate these RNA processing events remain poorly characterized. Among them are arginine-rich domains, most commonly sequences rich in arginine/serine (RS domains) or arginine/glycine/glycine (RGG boxes), that often appear among factors and complexes involved in RNA processing. They are emerging as key yet poorly understood players in the assembly and coupling of RNA processing events.
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subjects Animals
Arginine - analysis
Arginine - metabolism
Binding
Binding Sites
Biology
Bioscience
Calcium
Cancer
Cell
Cycle
Glycine - genetics
Glycine - metabolism
Humans
Landes
Methylation
Models, Biological
Organogenesis
Protein Structure, Tertiary
Proteins
RNA Precursors - metabolism
RNA Processing, Post-Transcriptional
RNA, Messenger - metabolism
RNA-Binding Proteins - chemistry
RNA-Binding Proteins - metabolism
title How Arginine-Rich Domains Coordinate mRNA Maturation Events
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