Random mutagenesis screening indicates the absence of a separate H+-sensor in the pH-sensitive Kir channels

Several inwardly-rectifying (Kir) potassium channels (Kir1.1, Kir4.1 and Kir4.2) are characterised by their sensitivity to inhibition by intracellular H + within the physiological range. The mechanism by which these channels are regulated by intracellular pH has been the subject of intense scrutiny...

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Veröffentlicht in:	Channels (Austin, Tex.) Tex.), 2010-09, Vol.4 (5), p.390-397
Hauptverfasser:	Paynter, Jennifer J., Shang, Lijun, Bollepalli, Murali K., Baukrowitz, Thomas, Tucker, Stephen J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Substitution Binding Biology Bioscience Calcium Cancer Cell Cycle Hydrogen-Ion Concentration Ion Channel Gating Landes Mutagenesis Organogenesis Potassium Channels, Inwardly Rectifying - chemistry Potassium Channels, Inwardly Rectifying - genetics Potassium Channels, Inwardly Rectifying - metabolism Protein Structure, Tertiary Proteins Research Paper Saccharomyces cerevisiae
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