Posttranscriptional Orchestration of an Anti-Apoptotic Program by HuR

The RNA-binding protein HuR can stabilize and/or regulate the translation of target mRNAs, thereby affecting the cellular responses to immune, proliferative, and damaging agents. Here, we discuss emerging evidence that HuR elicits a broad anti-apoptotic function through its influence on the expressi...

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Veröffentlicht in:	Cell cycle (Georgetown, Tex.) Tex.), 2007-06, Vol.6 (11), p.1288-1292
Hauptverfasser:	Abdelmohsen, Kotb, Lal, Ashish, Kim, Hyeon Ho, Gorospe, Myriam
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens, Surface - physiology Apoptosis - genetics Apoptosis - physiology Apoptosis Regulatory Proteins - biosynthesis Apoptosis Regulatory Proteins - genetics Binding Biology Bioscience Calcium Cancer Cell Cell Survival Cycle ELAV Proteins ELAV-Like Protein 1 Gene Expression Profiling Gene Expression Regulation - physiology Genes, bcl-2 HeLa Cells Humans Landes Myeloid Cell Leukemia Sequence 1 Protein Neoplasm Proteins - biosynthesis Neoplasm Proteins - genetics Organogenesis Protein Binding Protein Precursors - biosynthesis Protein Precursors - genetics Protein Precursors - metabolism Proteins Proto-Oncogene Proteins c-bcl-2 - biosynthesis Proto-Oncogene Proteins c-bcl-2 - genetics RNA Interference - physiology RNA, Messenger - metabolism RNA, Small Interfering - genetics RNA, Small Interfering - physiology RNA-Binding Proteins - physiology Sirtuin 1 Sirtuins - biosynthesis Sirtuins - genetics Sirtuins - physiology Thymosin - analogs & derivatives Thymosin - biosynthesis Thymosin - genetics Thymosin - metabolism Transfection
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