Genetic Screen for Chromosome Instability in Mice: Mcm4 and Breast Cancer

We recently isolated a hypomorphic mutation of Mcm4 in a phenotype-based screen for chromosome instability in mice. This mutation, named Chaos3 (Chromosome aberrations occurring spontaneously 3), causes exclusively mammary adenocarcinomas in ~80% of homozygous females. Mcm4 encodes a subunit of the...

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Veröffentlicht in:	Cell cycle (Georgetown, Tex.) Tex.), 2007-05, Vol.6 (10), p.1135-1140
Hauptverfasser:	Shima, Naoko, Buske, Tavanna R., Schimenti, John C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Binding Biology Bioscience Breast Neoplasms - genetics Calcium Cancer Cell Chromosomal Instability - genetics Cycle DNA Helicases - genetics DNA Replication - genetics Female Genetic Predisposition to Disease - genetics Genetic Testing Landes Mice Micronucleus Tests Minichromosome Maintenance Complex Component 4 Mutation - genetics Organogenesis Proteins
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