Oncogenes and the DNA Damage Response: Myc and E2F1 Engage the ATM Signaling Pathway to Activate p53 and Induce Apoptosis

Activation of the ATM DNA damage response pathway is commonly observed in avariety of early-stage neoplasias. It has been proposed that this checkpoint responsefunctions to suppress the development of cancer. A recent report from our laboratorydemonstrates that ATM does indeed function to suppress t...

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Veröffentlicht in:	Cell cycle (Georgetown, Tex.) Tex.), 2006-04, Vol.5 (8), p.801-803
Hauptverfasser:	Hong, Sungki, Pusapati, Raju V., Powers, John T., Johnson, David G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Ataxia Telangiectasia Mutated Proteins Binding Biology Bioscience Calcium Cancer Cell Cell Cycle Proteins - metabolism Cycle DNA Damage DNA-Binding Proteins - metabolism E2F1 Transcription Factor - metabolism E2F1 Transcription Factor - physiology Gene Expression Regulation, Neoplastic Genetic Predisposition to Disease Humans Landes Mice Mice, Transgenic Oncogenes Organogenesis Protein-Serine-Threonine Kinases - metabolism Proteins Proto-Oncogene Proteins c-myc - metabolism Proto-Oncogene Proteins c-myc - physiology Signal Transduction Tumor Suppressor Protein p53 - metabolism Tumor Suppressor Proteins - metabolism
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