Myc, Cdk2 and cellular senescence: Old players, new game

The aberrant activation of oncogenic pathways promotes tumor progression, but concomitantly elicits compensatory tumor-suppressive responses, such as apoptosis or senescence. For example, Ras induces senescence, while Myc generally triggers apoptosis. Myc is in fact viewed as an anti-senescence onco...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Cell cycle (Georgetown, Tex.) Tex.), 2010-09, Vol.9 (18), p.3679-3685
Hauptverfasser:	Campaner, Stefano, Doni, Mirko, Verrecchia, Alessandro, Fagà, Giovanni, Bianchi, Lucia, Amati, Bruno
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Binding Biology Bioscience Calcium Cancer Cell Cellular Senescence - physiology Cycle Cyclin-Dependent Kinase 2 - genetics Cyclin-Dependent Kinase 2 - metabolism Cyclin-Dependent Kinase Inhibitor p16 - metabolism Cyclin-Dependent Kinase Inhibitor p21 - metabolism Landes Mice Organogenesis Phosphorylation Proteins Proto-Oncogene Proteins c-myc - genetics Proto-Oncogene Proteins c-myc - metabolism ras Proteins - metabolism RecQ Helicases - metabolism Telomerase - metabolism Transforming Growth Factor beta - metabolism Tumor Suppressor Protein p53 - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!