Restoration of wild-type conformation to full-length and truncated p53 proteins: Specific effects of ATP and ADP

Mutations in the core domain of the tumor suppressor p53 gene occur in over 50% of human cancers and are not present in normal cells hence p53 protein is a prime target for anti-cancer therapy. In full-length p53 protein, mutations have been shown to destabilise protein structure from wild-type to m...

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