Phase I Study of Perillyl Alcohol in Patients with Refractory Malignancies

We treated 21 patients in a dose-finding and pharmacokinetic study of the monoterpene perillyl alcohol with the drug given orally in 3 divided doses on a chronic basis. The average number of days that patients remained on study was 48 (range 11-172). Fatigue and low-grade nausea were dose limiting....

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Veröffentlicht in:Cancer biology & therapy 2002-03, Vol.1 (2), p.124-129
Hauptverfasser: Kathleen Peccerillo, Giuseppe Pizzorno, Peter T. C. Ho, Walter McMurray, John R. Murren, Barbara A. Burtness, Thomas Rutherford, Ashwin Gollerkari, Xin Li, Susan A. DiStasio, Anne McKeon, Alan Sartorelli
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