Identification of thioredoxin reductase 1-regulated genes using small interference RNA and cDNA microarray

Thioredoxin reductase 1 (TrxR1) is a cytosolic enzyme that plays a central role in controlling cellular redox homeostasis. TrxR1 can transduce regulatory redox signals through the NADPH-dependent reduction of thioredoxin (Trx), which is able to reduce a broad spectrum of target enzymes and to regula...

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Veröffentlicht in:	Cancer biology & therapy 2005-10, Vol.4 (10), p.1079-1088
Hauptverfasser:	Gorreta, Francesco, Runfola, Timothy P., VanMeter, Amy J., Barzaghi, Dagania, Chandhoke, Vikas, Del Giacco, Luca
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding Biology Bioscience Calcium Cancer Cell Cell Line, Tumor Cycle Gene Expression Profiling Gene Expression Regulation - drug effects Gene Silencing Humans Landes Oligonucleotide Array Sequence Analysis Organogenesis Proteins RNA Interference RNA, Small Interfering - metabolism RNA, Small Interfering - pharmacology Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Thioredoxin Reductase 1 Thioredoxin-Disulfide Reductase - genetics
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