Targeting autophagy: The Achilles’ heel of cancer
In recent years, tremendous progress has been made toward unveiling the mechanism of autophagy and its exploitation by many different cancer types. This year the American Association for the Advancement of Science held a one day Symposium on Autophagy: An Emerging Therapeutic Target in Human Disease...
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| Veröffentlicht in: | Autophagy 2012-08, Vol.8 (8), p.1279-1280 |
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| container_title | Autophagy |
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| creator | Gorski, Sharon M Ries, Jenna Lum, Julian J |
| description | In recent years, tremendous progress has been made toward unveiling the mechanism of autophagy and its exploitation by many different cancer types. This year the American Association for the Advancement of Science held a one day Symposium on Autophagy: An Emerging Therapeutic Target in Human Disease in Vancouver, British Columbia and brought together experts in cell biology, drug discovery, and clinical translation to share their research findings and prospects. Currently, autophagy is being investigated on several fronts, from modulation of gene expression to in vivo studies, and more recently clinical trials in cancer. Key topics of discussion were determining which stage of autophagy would be the ideal target for inhibition to produce the highest impact, and which cancers or cancer subtypes would be the most sensitive to autophagy inhibitors; the answers to these questions may be a turning point in cancer therapy research. |
| doi_str_mv | 10.4161/auto.20828 |
| format | Article |
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| identifier | ISSN: 1554-8627 |
| ispartof | Autophagy, 2012-08, Vol.8 (8), p.1279-1280 |
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| language | eng |
| recordid | cdi_landesbioscience_primary_autophagy_article_20828 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Animals Autophagy Binding Biology Bioscience Calcium Cancer Cell Clinical Trials as Topic Cycle Disease Models, Animal Drug Resistance, Neoplasm - drug effects Endocytosis - drug effects Humans Landes Mice Neoplasms - drug therapy Neoplasms - pathology Organogenesis Protein Kinase Inhibitors - pharmacology Protein Kinase Inhibitors - therapeutic use Proteins |
| title | Targeting autophagy: The Achilles’ heel of cancer |
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