microRNA 30A promotes autophagy in response to cancer therapy

microRNAs (miRNAs) are a class of small regulatory RNAs that regulate gene expression at the post-transcriptional level. miRNAs play important roles in the regulation of development, growth, and metastasis of cancer, and in determining the response of tumor cells to anticancer therapy. In recent yea...

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Veröffentlicht in:	Autophagy 2012-05, Vol.8 (5), p.853-855
Hauptverfasser:	Yu, Yan, Cao, Lizhi, Yang, Liangchun, Kang, Rui, Lotze, Michael, Tang, Daolin
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis - drug effects Atg5 Autophagic Punctum autophagy Autophagy - drug effects Autophagy - genetics BCR-ABL tyrosine kinase Beclin 1 Benzamides Binding Biology Bioscience Calcium Cancer Cell chronic myelogenous leukemia Cycle Drug Resistance, Neoplasm - drug effects Gene Expression Regulation, Leukemic Humans Imatinib Mesylate Landes Leukemia, Myelogenous, Chronic, BCR-ABL Positive - drug therapy Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics Leukemia, Myelogenous, Chronic, BCR-ABL Positive - pathology microRNA MicroRNAs - genetics MicroRNAs - metabolism Models, Biological Neoplastic Stem Cells - drug effects Neoplastic Stem Cells - pathology Organogenesis Piperazines - pharmacology Piperazines - therapeutic use Protein Kinase Inhibitors - pharmacology Protein Kinase Inhibitors - therapeutic use Proteins Pyrimidines - pharmacology Pyrimidines - therapeutic use
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