ER stress negatively regulates AKT/TSC/mTOR pathway to enhance autophagy

Disturbance to endoplasmic reticulum (ER) homeostasis that can not be rescued by the unfolded protein response (UPR) results in autophagy and cell death, but the precise mechanism was largely unknown. Here we demonstrated that ER stress-induced cell death was mediated by autophagy which was partly a...

Ausführliche Beschreibung