정상인과 안검경련 환자에 있어서의 Fluorescein clearance test ( FCT ) 에 대한 연구

정상인과 안검경련 환자에 있어서의 Fluorescein clearance test ( FCT ) 에 대한 연구

알고있는 양과 농도의 fluorescein을 점안하고 일정시간이 지난 후 누액의 새로운 분비와 배출등에 의해 제거되어진 fluorescein의 양과 농도를 측정하여 누액 청소율(tear clearance)을 측정하는 검사가 Pflugfelder와 Tseng에 의하여 발표되었으나 측정시간에 길어, 저자들은 이 방법을 변형하여 그 유용성을 알아보고자 정상인 60안과, 본태성 안검경련환자 36안 및 반측안면경련환자 32안을 대상으로 fluorescein clearance test(FCT 1; 점안마취하에 0.25%, 20μl, fluor...

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Veröffentlicht in:Daihan angwa haghoi jabji 1996-03, Vol.37 (3), p.393-399
Hauptverfasser: 천중섭, Joong Sup Chun, 정한욱, Nam Ju Moon, 김재찬, Jae Chan Kim
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Dry eye
Esseutial Blepharosposm
Fluorescein clearance test
Hemifacial spasm
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container_end_page 399
container_issue 3
container_start_page 393
container_title Daihan angwa haghoi jabji
container_volume 37
creator 천중섭
Joong Sup Chun
정한욱
Nam Ju Moon
김재찬
Jae Chan Kim
description 알고있는 양과 농도의 fluorescein을 점안하고 일정시간이 지난 후 누액의 새로운 분비와 배출등에 의해 제거되어진 fluorescein의 양과 농도를 측정하여 누액 청소율(tear clearance)을 측정하는 검사가 Pflugfelder와 Tseng에 의하여 발표되었으나 측정시간에 길어, 저자들은 이 방법을 변형하여 그 유용성을 알아보고자 정상인 60안과, 본태성 안검경련환자 36안 및 반측안면경련환자 32안을 대상으로 fluorescein clearance test(FCT 1; 점안마취하에 0.25%, 20μl, fluorescein을 점안하고 10분후에 Schirmer 용지로 1분간 측정, FCT 2; FCT 1 시행 10분후 비강자극하에 Schirmer용지로 1분 측정)를 실시하였다. 묻어나온 fluorescein의 길이를 측정하고, fluorescein의 농도를 cobalt blue light하에 사진촬영하여 색의 짙은 정도에 따라 5단계로 나누어 판정하였다. 1명의 검사자가 2회 이상 판정했을 때 Intra-observer간에 일치도는 k=0.84이고, Inter-observer 일치도는 k=0.77로 높은 일치도(k>0.75)를 보였다. 또한 안구건조증이 흔히 동반되는 것으로 알려진 본태성 안검경 련환자군에서는 정상인에 비해 FCT 결과에서 짧은 fluorescein 측정길이(p
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fullrecord <record><control><sourceid>kiss_kyobo</sourceid><recordid>TN_cdi_kyobo_bookcenter_4010024300266</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><kiss_id>1965278</kiss_id><sourcerecordid>1965278</sourcerecordid><originalsourceid>FETCH-LOGICAL-k506-91c7fe9bcabcb68c1785b41c060c0cdfe1f3960c2b1e640ee970d77b51de0b613</originalsourceid><addsrcrecordid>eNotjDFPwlAUhTtoIkF-gctbTHRoci9t32tHQ0RNSFzYm77X26QBqenDgQ2jA4MDC4oJEEYHB4OaOOgfKo__YI0s53zDd86OVQFH-DZ3Be5ZNa1TCYDo-n6AFYvMcmLubs38q3j_ZmYyKlbDYvWzXr6wzfPULMbmaczMYmQeP8z9zMynrNm9yXLSitIeU12K8qiniPVJ99kRazba7Jj9bdYPw81kVuJb8fm6b-0mUVdTbdtVq908bTfO7dbl2UXjpGV3POB2gEokFEgVSSW5r1D4nnRRAQcFKk4IEycouS6RuAtEgYBYCOlhTCA5OlXr8P-2M8hkFsos6yjq9SkPXUCAuuuUwXnpHWy9VOvwOk-vonwQYsC9uvCdXwwsbZk</addsrcrecordid><sourcetype>Publisher</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>정상인과 안검경련 환자에 있어서의 Fluorescein clearance test ( FCT ) 에 대한 연구</title><source>KoreaMed Open Access</source><creator>천중섭 ; Joong Sup Chun ; 정한욱 ; Nam Ju Moon ; 김재찬 ; Jae Chan Kim</creator><creatorcontrib>천중섭 ; Joong Sup Chun ; 정한욱 ; Nam Ju Moon ; 김재찬 ; Jae Chan Kim</creatorcontrib><description>알고있는 양과 농도의 fluorescein을 점안하고 일정시간이 지난 후 누액의 새로운 분비와 배출등에 의해 제거되어진 fluorescein의 양과 농도를 측정하여 누액 청소율(tear clearance)을 측정하는 검사가 Pflugfelder와 Tseng에 의하여 발표되었으나 측정시간에 길어, 저자들은 이 방법을 변형하여 그 유용성을 알아보고자 정상인 60안과, 본태성 안검경련환자 36안 및 반측안면경련환자 32안을 대상으로 fluorescein clearance test(FCT 1; 점안마취하에 0.25%, 20μl, fluorescein을 점안하고 10분후에 Schirmer 용지로 1분간 측정, FCT 2; FCT 1 시행 10분후 비강자극하에 Schirmer용지로 1분 측정)를 실시하였다. 묻어나온 fluorescein의 길이를 측정하고, fluorescein의 농도를 cobalt blue light하에 사진촬영하여 색의 짙은 정도에 따라 5단계로 나누어 판정하였다. 1명의 검사자가 2회 이상 판정했을 때 Intra-observer간에 일치도는 k=0.84이고, Inter-observer 일치도는 k=0.77로 높은 일치도(k&gt;0.75)를 보였다. 또한 안구건조증이 흔히 동반되는 것으로 알려진 본태성 안검경 련환자군에서는 정상인에 비해 FCT 결과에서 짧은 fluorescein 측정길이(p&lt;0.001)를 보여 basal secretion의 감소를 보였으며 높은 fluorescein농도(p&lt;0.001)를 보여 지연된 청소율을 보였다. 따라서 농도판정에 있어서의 높은 재현성과 안구 건조증이 동반된 경우에 지연된 누액청 소율을 보이는 fluorescein clearance test sms 누액순환장애의 진단에 있어 유용한 검사방법으로 생각된다(한안지 37:393∼399, 1996). On the proposed fluorescein clearance test by Pflugfelder &amp; Tseng, measurements of volume and concentration of instilled fluorescein, being descern tear turnover rate(tear clearance). We performed TBUT, Schirmer test and modified FCT to the 60 eyes of healthy person, to the 36 eyes of essential blepharospasm patient, and to the 32 eyes of hemifacial spasm patients. We modified the FCT to economize time. Under the topical anesthesia with 0.5% propacaine, test was performed after instilling a 20μl of Flucaine(0.25% fluorescein sodium, and 0.5% propacaine) into the conjunctival sac and standard Schirmer strip was then placed for another 10 minutes. The length of the portion was measured and the concentration of tint fluorescein was graded into 5 degrees(photodocumented classification under the cobalt blue light) (FCT 1). Waiting 10 minutes, a standard Schirmer strip was placed into with nasal stimulation and length and concentration was also measured(FCT 2). The agreement of classification was determined with Kappa values for evaluation for reproducibility and reliability of FCT. The intra-observer agreement(examination repeated twice) was k=0.84 and the inter-observer agreement(two obsevers` examination) was k=0.77, which revealed a consistent result. Patients with blepharospasm was indicated decreased basal secretion compared with normal control(p&lt;0.001) and also showed delayed tear clearance whith represented significant increased concentration(p&lt;0.001). We concluded that FCT was revealed high reproducibility by intra-observer and inter-observer agreement and test may be useful diagnostic method to evaluate delayed tear clearance(J Korean Ophthalmol Soc 37:393∼399, 1996).</description><identifier>ISSN: 0378-6471</identifier><language>kor</language><publisher>대한안과학회</publisher><subject>Dry eye ; Esseutial Blepharosposm ; Fluorescein clearance test ; Hemifacial spasm</subject><ispartof>Daihan angwa haghoi jabji, 1996-03, Vol.37 (3), p.393-399</ispartof><rights>COPYRIGHT(C) KYOBO BOOK CENTRE ALL RIGHTS RESERVED</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids></links><search><creatorcontrib>천중섭</creatorcontrib><creatorcontrib>Joong Sup Chun</creatorcontrib><creatorcontrib>정한욱</creatorcontrib><creatorcontrib>Nam Ju Moon</creatorcontrib><creatorcontrib>김재찬</creatorcontrib><creatorcontrib>Jae Chan Kim</creatorcontrib><title>정상인과 안검경련 환자에 있어서의 Fluorescein clearance test ( FCT ) 에 대한 연구</title><title>Daihan angwa haghoi jabji</title><addtitle>대한안과학회지</addtitle><description>알고있는 양과 농도의 fluorescein을 점안하고 일정시간이 지난 후 누액의 새로운 분비와 배출등에 의해 제거되어진 fluorescein의 양과 농도를 측정하여 누액 청소율(tear clearance)을 측정하는 검사가 Pflugfelder와 Tseng에 의하여 발표되었으나 측정시간에 길어, 저자들은 이 방법을 변형하여 그 유용성을 알아보고자 정상인 60안과, 본태성 안검경련환자 36안 및 반측안면경련환자 32안을 대상으로 fluorescein clearance test(FCT 1; 점안마취하에 0.25%, 20μl, fluorescein을 점안하고 10분후에 Schirmer 용지로 1분간 측정, FCT 2; FCT 1 시행 10분후 비강자극하에 Schirmer용지로 1분 측정)를 실시하였다. 묻어나온 fluorescein의 길이를 측정하고, fluorescein의 농도를 cobalt blue light하에 사진촬영하여 색의 짙은 정도에 따라 5단계로 나누어 판정하였다. 1명의 검사자가 2회 이상 판정했을 때 Intra-observer간에 일치도는 k=0.84이고, Inter-observer 일치도는 k=0.77로 높은 일치도(k&gt;0.75)를 보였다. 또한 안구건조증이 흔히 동반되는 것으로 알려진 본태성 안검경 련환자군에서는 정상인에 비해 FCT 결과에서 짧은 fluorescein 측정길이(p&lt;0.001)를 보여 basal secretion의 감소를 보였으며 높은 fluorescein농도(p&lt;0.001)를 보여 지연된 청소율을 보였다. 따라서 농도판정에 있어서의 높은 재현성과 안구 건조증이 동반된 경우에 지연된 누액청 소율을 보이는 fluorescein clearance test sms 누액순환장애의 진단에 있어 유용한 검사방법으로 생각된다(한안지 37:393∼399, 1996). On the proposed fluorescein clearance test by Pflugfelder &amp; Tseng, measurements of volume and concentration of instilled fluorescein, being descern tear turnover rate(tear clearance). We performed TBUT, Schirmer test and modified FCT to the 60 eyes of healthy person, to the 36 eyes of essential blepharospasm patient, and to the 32 eyes of hemifacial spasm patients. We modified the FCT to economize time. Under the topical anesthesia with 0.5% propacaine, test was performed after instilling a 20μl of Flucaine(0.25% fluorescein sodium, and 0.5% propacaine) into the conjunctival sac and standard Schirmer strip was then placed for another 10 minutes. The length of the portion was measured and the concentration of tint fluorescein was graded into 5 degrees(photodocumented classification under the cobalt blue light) (FCT 1). Waiting 10 minutes, a standard Schirmer strip was placed into with nasal stimulation and length and concentration was also measured(FCT 2). The agreement of classification was determined with Kappa values for evaluation for reproducibility and reliability of FCT. The intra-observer agreement(examination repeated twice) was k=0.84 and the inter-observer agreement(two obsevers` examination) was k=0.77, which revealed a consistent result. Patients with blepharospasm was indicated decreased basal secretion compared with normal control(p&lt;0.001) and also showed delayed tear clearance whith represented significant increased concentration(p&lt;0.001). We concluded that FCT was revealed high reproducibility by intra-observer and inter-observer agreement and test may be useful diagnostic method to evaluate delayed tear clearance(J Korean Ophthalmol Soc 37:393∼399, 1996).</description><subject>Dry eye</subject><subject>Esseutial Blepharosposm</subject><subject>Fluorescein clearance test</subject><subject>Hemifacial spasm</subject><issn>0378-6471</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><recordid>eNotjDFPwlAUhTtoIkF-gctbTHRoci9t32tHQ0RNSFzYm77X26QBqenDgQ2jA4MDC4oJEEYHB4OaOOgfKo__YI0s53zDd86OVQFH-DZ3Be5ZNa1TCYDo-n6AFYvMcmLubs38q3j_ZmYyKlbDYvWzXr6wzfPULMbmaczMYmQeP8z9zMynrNm9yXLSitIeU12K8qiniPVJ99kRazba7Jj9bdYPw81kVuJb8fm6b-0mUVdTbdtVq908bTfO7dbl2UXjpGV3POB2gEokFEgVSSW5r1D4nnRRAQcFKk4IEycouS6RuAtEgYBYCOlhTCA5OlXr8P-2M8hkFsos6yjq9SkPXUCAuuuUwXnpHWy9VOvwOk-vonwQYsC9uvCdXwwsbZk</recordid><startdate>19960315</startdate><enddate>19960315</enddate><creator>천중섭</creator><creator>Joong Sup Chun</creator><creator>정한욱</creator><creator>Nam Ju Moon</creator><creator>김재찬</creator><creator>Jae Chan Kim</creator><general>대한안과학회</general><scope>HZB</scope><scope>Q5X</scope><scope>P5Y</scope><scope>SSSTE</scope></search><sort><creationdate>19960315</creationdate><title>정상인과 안검경련 환자에 있어서의 Fluorescein clearance test ( FCT ) 에 대한 연구</title><author>천중섭 ; Joong Sup Chun ; 정한욱 ; Nam Ju Moon ; 김재찬 ; Jae Chan Kim</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-k506-91c7fe9bcabcb68c1785b41c060c0cdfe1f3960c2b1e640ee970d77b51de0b613</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>kor</language><creationdate>1996</creationdate><topic>Dry eye</topic><topic>Esseutial Blepharosposm</topic><topic>Fluorescein clearance test</topic><topic>Hemifacial spasm</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>천중섭</creatorcontrib><creatorcontrib>Joong Sup Chun</creatorcontrib><creatorcontrib>정한욱</creatorcontrib><creatorcontrib>Nam Ju Moon</creatorcontrib><creatorcontrib>김재찬</creatorcontrib><creatorcontrib>Jae Chan Kim</creatorcontrib><collection>Korean Studies Information Service System (KISS)</collection><collection>Korean Studies Information Service System (KISS) B-Type</collection><collection>Kyobo Scholar (교보스콜라)</collection><collection>Scholar(스콜라)</collection><jtitle>Daihan angwa haghoi jabji</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>천중섭</au><au>Joong Sup Chun</au><au>정한욱</au><au>Nam Ju Moon</au><au>김재찬</au><au>Jae Chan Kim</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>정상인과 안검경련 환자에 있어서의 Fluorescein clearance test ( FCT ) 에 대한 연구</atitle><jtitle>Daihan angwa haghoi jabji</jtitle><addtitle>대한안과학회지</addtitle><date>1996-03-15</date><risdate>1996</risdate><volume>37</volume><issue>3</issue><spage>393</spage><epage>399</epage><pages>393-399</pages><issn>0378-6471</issn><abstract>알고있는 양과 농도의 fluorescein을 점안하고 일정시간이 지난 후 누액의 새로운 분비와 배출등에 의해 제거되어진 fluorescein의 양과 농도를 측정하여 누액 청소율(tear clearance)을 측정하는 검사가 Pflugfelder와 Tseng에 의하여 발표되었으나 측정시간에 길어, 저자들은 이 방법을 변형하여 그 유용성을 알아보고자 정상인 60안과, 본태성 안검경련환자 36안 및 반측안면경련환자 32안을 대상으로 fluorescein clearance test(FCT 1; 점안마취하에 0.25%, 20μl, fluorescein을 점안하고 10분후에 Schirmer 용지로 1분간 측정, FCT 2; FCT 1 시행 10분후 비강자극하에 Schirmer용지로 1분 측정)를 실시하였다. 묻어나온 fluorescein의 길이를 측정하고, fluorescein의 농도를 cobalt blue light하에 사진촬영하여 색의 짙은 정도에 따라 5단계로 나누어 판정하였다. 1명의 검사자가 2회 이상 판정했을 때 Intra-observer간에 일치도는 k=0.84이고, Inter-observer 일치도는 k=0.77로 높은 일치도(k&gt;0.75)를 보였다. 또한 안구건조증이 흔히 동반되는 것으로 알려진 본태성 안검경 련환자군에서는 정상인에 비해 FCT 결과에서 짧은 fluorescein 측정길이(p&lt;0.001)를 보여 basal secretion의 감소를 보였으며 높은 fluorescein농도(p&lt;0.001)를 보여 지연된 청소율을 보였다. 따라서 농도판정에 있어서의 높은 재현성과 안구 건조증이 동반된 경우에 지연된 누액청 소율을 보이는 fluorescein clearance test sms 누액순환장애의 진단에 있어 유용한 검사방법으로 생각된다(한안지 37:393∼399, 1996). On the proposed fluorescein clearance test by Pflugfelder &amp; Tseng, measurements of volume and concentration of instilled fluorescein, being descern tear turnover rate(tear clearance). We performed TBUT, Schirmer test and modified FCT to the 60 eyes of healthy person, to the 36 eyes of essential blepharospasm patient, and to the 32 eyes of hemifacial spasm patients. We modified the FCT to economize time. Under the topical anesthesia with 0.5% propacaine, test was performed after instilling a 20μl of Flucaine(0.25% fluorescein sodium, and 0.5% propacaine) into the conjunctival sac and standard Schirmer strip was then placed for another 10 minutes. The length of the portion was measured and the concentration of tint fluorescein was graded into 5 degrees(photodocumented classification under the cobalt blue light) (FCT 1). Waiting 10 minutes, a standard Schirmer strip was placed into with nasal stimulation and length and concentration was also measured(FCT 2). The agreement of classification was determined with Kappa values for evaluation for reproducibility and reliability of FCT. The intra-observer agreement(examination repeated twice) was k=0.84 and the inter-observer agreement(two obsevers` examination) was k=0.77, which revealed a consistent result. Patients with blepharospasm was indicated decreased basal secretion compared with normal control(p&lt;0.001) and also showed delayed tear clearance whith represented significant increased concentration(p&lt;0.001). We concluded that FCT was revealed high reproducibility by intra-observer and inter-observer agreement and test may be useful diagnostic method to evaluate delayed tear clearance(J Korean Ophthalmol Soc 37:393∼399, 1996).</abstract><pub>대한안과학회</pub><tpages>7</tpages></addata></record>
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identifier ISSN: 0378-6471
ispartof Daihan angwa haghoi jabji, 1996-03, Vol.37 (3), p.393-399
issn 0378-6471
language kor
recordid cdi_kyobo_bookcenter_4010024300266
source KoreaMed Open Access
subjects Dry eye
Esseutial Blepharosposm
Fluorescein clearance test
Hemifacial spasm
title 정상인과 안검경련 환자에 있어서의 Fluorescein clearance test ( FCT ) 에 대한 연구
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