Intratumoral delivery of lipid nanoparticle-formulated mRNA encoding IL-21, IL-7, and 4-1BBL induces systemic anti-tumor immunity

Local delivery of mRNA-based immunotherapy offers a promising avenue as it enables the production of specific immunomodulatory proteins that can stimulate the immune system to recognize and eliminate cancer cells while limiting systemic exposure and toxicities. Here, we develop and employ lipid-base...

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Veröffentlicht in:	NATURE COMMUNICATIONS 2024-12, Vol.15 (1)
Hauptverfasser:	Hamouda, Ahmed E.I, Filtjens, Jessica, Brabants, Elisabeth, Kancheva, Daliya, Debraekeleer, Ayla, Brughmans, Jan, Jacobs, Lotte, Bardet, Pauline M.R, Knetemann, Elisabeth, Lefesvre, Pierre, Allonsius, Lize, Gontsarik, Mark, Varela, Ismael, Crabbe, Marian, Clappaert, Emile J, Cappellesso, Federica, Caro, Aarushi A, Peiro, Alicia Gordun, Fredericq, Luna, Hadadi, Eva, Senti, Mariona Estape, Schiffelers, Raymond, van Grunsven, Leo A, Nana, Frank Aboubakar, De Geest, Bruno G, Deschoemaeker, Sofie, De Koker, Stefaan, Lambolez, Florence, Laoui, Damya
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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