Legius syndrome mutations in the Ras-regulator SPRED1 abolish its membrane localization and potentially cause neurodegeneration

The SPRED family proteins act as negative regulators of the Ras-ERK pathway: the N-terminal EVH1 domain interacts with the Ras-GAP domain (GRD) of the NF1 protein, while the C-terminal Sprouty-related (SPR) domain promotes membrane localization of SPRED, thereby recruiting NF-1 to Ras. Loss-of-funct...

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Veröffentlicht in:	JOURNAL OF BIOLOGICAL CHEMISTRY 2024-12, Vol.300 (12)
Hauptverfasser:	Hirata, Yasuko, Brems, Hilde, van der Auweraer, Seppe, Ohyagi, Masaki, Iizuka, Mana, Mise-Omata, Setsuko, Ito, Minako, Messiaen, Ludwine, Mizuno, Seiya, Takahashi, Satoru, Legius, Eric, Yoshimura, Akihiko
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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