Left ventricular volume as a predictor of exercise capacity and functional independence in individuals with normal ejection fraction
AIMS: Low cardiorespiratory fitness (CRF) is associated with functional disability, heart failure and mortality. Left ventricular (LV) end-diastolic volume (LVEDV) has been linked with CRF, but its utility as a diagnostic marker of low CRF has not been tested. METHODS: This multi-center internationa...
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| creator | Rowe, Stephanie L'Hoyes, Wouter Milani, Mauricio Spencer, Luke Foulkes, Stephen Paratz, Elizabeth Janssens, Kristel Stassen, Jan Delpire, Boris Pauwels, Rik Moura-Ferreira, Sara Falter, Maarten Bekhuis, Youri Herbots, Lieven Haykowsky, Mark J Claessen, Guido La Gerche, Andre Verwerft, Jan |
| description | AIMS: Low cardiorespiratory fitness (CRF) is associated with functional disability, heart failure and mortality. Left ventricular (LV) end-diastolic volume (LVEDV) has been linked with CRF, but its utility as a diagnostic marker of low CRF has not been tested. METHODS: This multi-center international cohort examined the relationship between LV size on echocardiography and CRF (peak oxygen uptake [peak VO2] from cardiopulmonary exercise testing) in individuals with LV ejection fraction ≥50%. Absolute and BSA-indexed LVEDV (LVEDVi) were tested as predictors of low CRF and functional disability (peak VO2 |
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| fullrecord | <record><control><sourceid>kuleuven</sourceid><recordid>TN_cdi_kuleuven_dspace_20_500_12942_753603</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>20_500_12942_753603</sourcerecordid><originalsourceid>FETCH-kuleuven_dspace_20_500_12942_7536033</originalsourceid><addsrcrecordid>eNqVjk1OAzEMhbMAiar0Dl4jFYVk2hnWCMSCJfvIShzhkiaj_Axlz8EJFQcAL579pM_PvhArJYdxO0yjvhKbUg6y114qNU0r8fVCvsJCsWa2LWCGJYV2JMACCHMmx7amDMkDnShbLgQWZ7RcPwGjA9-irZwiBuDoaKYu0VI3P54Xdg1DgQ-ubxBTPnaODnReAZ_xPFyLS98h2vz2tbh5enx9eN6-t0CtP2dc6SfJKGl2Upo7dT8oM-70Xmq9Frd_hk09Vf2v9G-rNWSZ</addsrcrecordid><sourcetype>Institutional Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Left ventricular volume as a predictor of exercise capacity and functional independence in individuals with normal ejection fraction</title><source>Lirias (KU Leuven Association)</source><source>Oxford University Press Journals All Titles (1996-Current)</source><creator>Rowe, Stephanie ; L'Hoyes, Wouter ; Milani, Mauricio ; Spencer, Luke ; Foulkes, Stephen ; Paratz, Elizabeth ; Janssens, Kristel ; Stassen, Jan ; Delpire, Boris ; Pauwels, Rik ; Moura-Ferreira, Sara ; Falter, Maarten ; Bekhuis, Youri ; Herbots, Lieven ; Haykowsky, Mark J ; Claessen, Guido ; La Gerche, Andre ; Verwerft, Jan</creator><creatorcontrib>Rowe, Stephanie ; L'Hoyes, Wouter ; Milani, Mauricio ; Spencer, Luke ; Foulkes, Stephen ; Paratz, Elizabeth ; Janssens, Kristel ; Stassen, Jan ; Delpire, Boris ; Pauwels, Rik ; Moura-Ferreira, Sara ; Falter, Maarten ; Bekhuis, Youri ; Herbots, Lieven ; Haykowsky, Mark J ; Claessen, Guido ; La Gerche, Andre ; Verwerft, Jan</creatorcontrib><description>AIMS: Low cardiorespiratory fitness (CRF) is associated with functional disability, heart failure and mortality. Left ventricular (LV) end-diastolic volume (LVEDV) has been linked with CRF, but its utility as a diagnostic marker of low CRF has not been tested. METHODS: This multi-center international cohort examined the relationship between LV size on echocardiography and CRF (peak oxygen uptake [peak VO2] from cardiopulmonary exercise testing) in individuals with LV ejection fraction ≥50%. Absolute and BSA-indexed LVEDV (LVEDVi) were tested as predictors of low CRF and functional disability (peak VO2 <1100ml/min or <18 ml/kg/min) and compared against candidate measures of cardiac structure and function. RESULTS: 2876 individuals (309 endurance athletes, 251 healthy non-athletes, 1969 individuals with unexplained dyspnea, 347 individuals with heart failure with preserved ejection fraction) were included. For the entire cohort, LVEDV had the strongest univariable association with peak VO2 (R2 =0.45, standardized [std]β 0.67, p<0.001) and remained the strongest independent predictor of peak VO2 after adjusting for age, sex and BMI (stdβ 0.30, p<0.001). LVEDV was better at identifying low CRF than most established echocardiographic measures (LVEDV AUC 0.72; LVEDVi AUC 0.71), but equivalent to the E/e' ratio. The probability of achieving a peak VO2 below the functional independence threshold was highest for smaller ventricular volumes, with LVEDV and LVEDVi of 88ml and 57ml/m2 providing the optimal cut-points, respectively. CONCLUSIONS: Small resting ventricular size is associated with a higher probability of low CRF and functional disability. LV size is the strongest independent echocardiographic predictor of CRF across the health-disease continuum.</description><identifier>ISSN: 2047-4873</identifier><language>eng</language><publisher>OXFORD UNIV PRESS</publisher><ispartof>EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY, 2024-11</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,315,777,781,27841</link.rule.ids></links><search><creatorcontrib>Rowe, Stephanie</creatorcontrib><creatorcontrib>L'Hoyes, Wouter</creatorcontrib><creatorcontrib>Milani, Mauricio</creatorcontrib><creatorcontrib>Spencer, Luke</creatorcontrib><creatorcontrib>Foulkes, Stephen</creatorcontrib><creatorcontrib>Paratz, Elizabeth</creatorcontrib><creatorcontrib>Janssens, Kristel</creatorcontrib><creatorcontrib>Stassen, Jan</creatorcontrib><creatorcontrib>Delpire, Boris</creatorcontrib><creatorcontrib>Pauwels, Rik</creatorcontrib><creatorcontrib>Moura-Ferreira, Sara</creatorcontrib><creatorcontrib>Falter, Maarten</creatorcontrib><creatorcontrib>Bekhuis, Youri</creatorcontrib><creatorcontrib>Herbots, Lieven</creatorcontrib><creatorcontrib>Haykowsky, Mark J</creatorcontrib><creatorcontrib>Claessen, Guido</creatorcontrib><creatorcontrib>La Gerche, Andre</creatorcontrib><creatorcontrib>Verwerft, Jan</creatorcontrib><title>Left ventricular volume as a predictor of exercise capacity and functional independence in individuals with normal ejection fraction</title><title>EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY</title><description>AIMS: Low cardiorespiratory fitness (CRF) is associated with functional disability, heart failure and mortality. Left ventricular (LV) end-diastolic volume (LVEDV) has been linked with CRF, but its utility as a diagnostic marker of low CRF has not been tested. METHODS: This multi-center international cohort examined the relationship between LV size on echocardiography and CRF (peak oxygen uptake [peak VO2] from cardiopulmonary exercise testing) in individuals with LV ejection fraction ≥50%. Absolute and BSA-indexed LVEDV (LVEDVi) were tested as predictors of low CRF and functional disability (peak VO2 <1100ml/min or <18 ml/kg/min) and compared against candidate measures of cardiac structure and function. RESULTS: 2876 individuals (309 endurance athletes, 251 healthy non-athletes, 1969 individuals with unexplained dyspnea, 347 individuals with heart failure with preserved ejection fraction) were included. For the entire cohort, LVEDV had the strongest univariable association with peak VO2 (R2 =0.45, standardized [std]β 0.67, p<0.001) and remained the strongest independent predictor of peak VO2 after adjusting for age, sex and BMI (stdβ 0.30, p<0.001). LVEDV was better at identifying low CRF than most established echocardiographic measures (LVEDV AUC 0.72; LVEDVi AUC 0.71), but equivalent to the E/e' ratio. The probability of achieving a peak VO2 below the functional independence threshold was highest for smaller ventricular volumes, with LVEDV and LVEDVi of 88ml and 57ml/m2 providing the optimal cut-points, respectively. CONCLUSIONS: Small resting ventricular size is associated with a higher probability of low CRF and functional disability. LV size is the strongest independent echocardiographic predictor of CRF across the health-disease continuum.</description><issn>2047-4873</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>FZOIL</sourceid><recordid>eNqVjk1OAzEMhbMAiar0Dl4jFYVk2hnWCMSCJfvIShzhkiaj_Axlz8EJFQcAL579pM_PvhArJYdxO0yjvhKbUg6y114qNU0r8fVCvsJCsWa2LWCGJYV2JMACCHMmx7amDMkDnShbLgQWZ7RcPwGjA9-irZwiBuDoaKYu0VI3P54Xdg1DgQ-ubxBTPnaODnReAZ_xPFyLS98h2vz2tbh5enx9eN6-t0CtP2dc6SfJKGl2Upo7dT8oM-70Xmq9Frd_hk09Vf2v9G-rNWSZ</recordid><startdate>20241104</startdate><enddate>20241104</enddate><creator>Rowe, Stephanie</creator><creator>L'Hoyes, Wouter</creator><creator>Milani, Mauricio</creator><creator>Spencer, Luke</creator><creator>Foulkes, Stephen</creator><creator>Paratz, Elizabeth</creator><creator>Janssens, Kristel</creator><creator>Stassen, Jan</creator><creator>Delpire, Boris</creator><creator>Pauwels, Rik</creator><creator>Moura-Ferreira, Sara</creator><creator>Falter, Maarten</creator><creator>Bekhuis, Youri</creator><creator>Herbots, Lieven</creator><creator>Haykowsky, Mark J</creator><creator>Claessen, Guido</creator><creator>La Gerche, Andre</creator><creator>Verwerft, Jan</creator><general>OXFORD UNIV PRESS</general><scope>FZOIL</scope></search><sort><creationdate>20241104</creationdate><title>Left ventricular volume as a predictor of exercise capacity and functional independence in individuals with normal ejection fraction</title><author>Rowe, Stephanie ; L'Hoyes, Wouter ; Milani, Mauricio ; Spencer, Luke ; Foulkes, Stephen ; Paratz, Elizabeth ; Janssens, Kristel ; Stassen, Jan ; Delpire, Boris ; Pauwels, Rik ; Moura-Ferreira, Sara ; Falter, Maarten ; Bekhuis, Youri ; Herbots, Lieven ; Haykowsky, Mark J ; Claessen, Guido ; La Gerche, Andre ; Verwerft, Jan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-kuleuven_dspace_20_500_12942_7536033</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rowe, Stephanie</creatorcontrib><creatorcontrib>L'Hoyes, Wouter</creatorcontrib><creatorcontrib>Milani, Mauricio</creatorcontrib><creatorcontrib>Spencer, Luke</creatorcontrib><creatorcontrib>Foulkes, Stephen</creatorcontrib><creatorcontrib>Paratz, Elizabeth</creatorcontrib><creatorcontrib>Janssens, Kristel</creatorcontrib><creatorcontrib>Stassen, Jan</creatorcontrib><creatorcontrib>Delpire, Boris</creatorcontrib><creatorcontrib>Pauwels, Rik</creatorcontrib><creatorcontrib>Moura-Ferreira, Sara</creatorcontrib><creatorcontrib>Falter, Maarten</creatorcontrib><creatorcontrib>Bekhuis, Youri</creatorcontrib><creatorcontrib>Herbots, Lieven</creatorcontrib><creatorcontrib>Haykowsky, Mark J</creatorcontrib><creatorcontrib>Claessen, Guido</creatorcontrib><creatorcontrib>La Gerche, Andre</creatorcontrib><creatorcontrib>Verwerft, Jan</creatorcontrib><collection>Lirias (KU Leuven Association)</collection><jtitle>EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rowe, Stephanie</au><au>L'Hoyes, Wouter</au><au>Milani, Mauricio</au><au>Spencer, Luke</au><au>Foulkes, Stephen</au><au>Paratz, Elizabeth</au><au>Janssens, Kristel</au><au>Stassen, Jan</au><au>Delpire, Boris</au><au>Pauwels, Rik</au><au>Moura-Ferreira, Sara</au><au>Falter, Maarten</au><au>Bekhuis, Youri</au><au>Herbots, Lieven</au><au>Haykowsky, Mark J</au><au>Claessen, Guido</au><au>La Gerche, Andre</au><au>Verwerft, Jan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Left ventricular volume as a predictor of exercise capacity and functional independence in individuals with normal ejection fraction</atitle><jtitle>EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY</jtitle><date>2024-11-04</date><risdate>2024</risdate><issn>2047-4873</issn><abstract>AIMS: Low cardiorespiratory fitness (CRF) is associated with functional disability, heart failure and mortality. Left ventricular (LV) end-diastolic volume (LVEDV) has been linked with CRF, but its utility as a diagnostic marker of low CRF has not been tested. METHODS: This multi-center international cohort examined the relationship between LV size on echocardiography and CRF (peak oxygen uptake [peak VO2] from cardiopulmonary exercise testing) in individuals with LV ejection fraction ≥50%. Absolute and BSA-indexed LVEDV (LVEDVi) were tested as predictors of low CRF and functional disability (peak VO2 <1100ml/min or <18 ml/kg/min) and compared against candidate measures of cardiac structure and function. RESULTS: 2876 individuals (309 endurance athletes, 251 healthy non-athletes, 1969 individuals with unexplained dyspnea, 347 individuals with heart failure with preserved ejection fraction) were included. For the entire cohort, LVEDV had the strongest univariable association with peak VO2 (R2 =0.45, standardized [std]β 0.67, p<0.001) and remained the strongest independent predictor of peak VO2 after adjusting for age, sex and BMI (stdβ 0.30, p<0.001). LVEDV was better at identifying low CRF than most established echocardiographic measures (LVEDV AUC 0.72; LVEDVi AUC 0.71), but equivalent to the E/e' ratio. The probability of achieving a peak VO2 below the functional independence threshold was highest for smaller ventricular volumes, with LVEDV and LVEDVi of 88ml and 57ml/m2 providing the optimal cut-points, respectively. CONCLUSIONS: Small resting ventricular size is associated with a higher probability of low CRF and functional disability. LV size is the strongest independent echocardiographic predictor of CRF across the health-disease continuum.</abstract><pub>OXFORD UNIV PRESS</pub></addata></record> |
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| source | Lirias (KU Leuven Association); Oxford University Press Journals All Titles (1996-Current) |
| title | Left ventricular volume as a predictor of exercise capacity and functional independence in individuals with normal ejection fraction |
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