A Phase 1a/1b Study of Fostroxacitabine Bralpamide (Fostrox) Monotherapy in Hepatocellular Carcinoma and Solid Tumor Liver Metastases

PURPOSE: To evaluate safety, preliminary efficacy, pharmacokinetics, and pharmacodynamics, of fostroxacitabine bralpamide (fostrox, MIV-818), a novel oral troxacitabine nucleotide prodrug designed to direct exposure to the liver, while minimizing systemic toxicity. PATIENTS AND METHODS: Fostrox mono...

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Veröffentlicht in:	JOURNAL OF HEPATOCELLULAR CARCINOMA 2024, Vol.11, p.2033-2047
Hauptverfasser:	Plummer, Ruth, Greystoke, Alastair, Naylor, Gregory, Sarker, Debashis, Anam, A.N.M. Kaiser, Prenen, Hans, Teuwen, Laure-Anne, Van Cutsem, Eric, Dekervel, Jeroen, Haugk, Beate, Ness, Thomas, Bhoi, Sujata, Jensen, Malene, Morris, Tom, Baumann, Pia, Sjogren, Niclas, Tunblad, Karin, Wallberg, Hans, Oberg, Fredrik, Evans, Thomas R. Jeffry
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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