Focal deletions of a promoter tether activate the IRX3 oncogene in T-cell acute lymphoblastic leukemia

Oncogenes can be activated in cis through multiple mechanisms including enhancer hijacking events and noncoding mutations that create enhancers or promoters de novo. These paradigms have helped parse somatic variation of noncoding cancer genomes, thereby providing a rationale to identify noncanonica...

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Veröffentlicht in:	Blood 2024-09, p.blood.2024024300
Hauptverfasser:	Rahman, Sunniyat, Bloye, Gianna, Farah, Nadine, Demeulemeester, Jonas, Costa, Joana R, O'Connor, David, Pocock, Rachael, Rapoz-D'Silva, Tanya, Turna, Adam, Wang, Lingyi, Lee, Soo Wah, Fielding, Adele K, Roels, Juliette, Jaksik, Roman, Dawidowska, Małgorzata, Van Vlierberghe, Pieter, Hadjur, Suzana, Hughes, Jim R, Davies, James, Gutierrez, Alejandro, Kelliher, Michelle, Van Loo, Peter, Dawson, Mark A, Mansour, Marc R
Format:	Artikel
Sprache:	eng
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