The genomic evolutionary dynamics and global circulation patterns of respiratory syncytial virus
Respiratory syncytial virus (RSV) is a leading cause of acute lower respiratory tract infection in young children and the second leading cause of infant death worldwide. While global circulation has been extensively studied for respiratory viruses such as seasonal influenza, and more recently also i...
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| Veröffentlicht in: | NATURE COMMUNICATIONS 2024-04, Vol.15 (1) |
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| creator | Langedijk, Annefleur C Vrancken, Bram Lebbink, Robert Jan Wilkins, Deidre Kelly, Elizabeth J Baraldi, Eugenio Mascarenas de los Santos, Abiel Homero Danilenko, Daria M Choi, Eun Hwa Palomino, Maria Angelica Chi, Hsin Keller, Christian Cohen, Robert Papenburg, Jesse Pernica, Jeffrey Greenough, Anne Richmond, Peter Martinon-Torres, Federico Heikkinen, Terho Stein, Renato T Hosoya, Mitsuaki Nunes, Marta C Verwey, Charl Evers, Anouk Kragten-Tabatabaie, Leyla Suchard, Marc A Kosakovsky Pond, Sergei L Poletto, Chiara Colizza, Vittoria Lemey, Philippe Bont, Louis J |
| description | Respiratory syncytial virus (RSV) is a leading cause of acute lower respiratory tract infection in young children and the second leading cause of infant death worldwide. While global circulation has been extensively studied for respiratory viruses such as seasonal influenza, and more recently also in great detail for SARS-CoV-2, a lack of global multi-annual sampling of complete RSV genomes limits our understanding of RSV molecular epidemiology. Here, we capitalise on the genomic surveillance by the INFORM-RSV study and apply phylodynamic approaches to uncover how selection and neutral epidemiological processes shape RSV diversity. Using complete viral genome sequences, we show similar patterns of site-specific diversifying selection among RSVA and RSVB and recover the imprint of non-neutral epidemic processes on their genealogies. Using a phylogeographic approach, we provide evidence for air travel governing the global patterns of RSVA and RSVB spread, which results in a considerable degree of phylogenetic mixing across countries. Our findings highlight the potential of systematic global RSV genomic surveillance for transforming our understanding of global RSV spread. |
| format | Article |
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| title | The genomic evolutionary dynamics and global circulation patterns of respiratory syncytial virus |
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