PP2A and GSK3 act as modifiers of FUS-ALS by modulating mitochondrial transport

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease which currently lacks effective treatments. Mutations in the RNA-binding protein FUS are a common cause of familial ALS, accounting for around 4% of the cases. Understanding the mechanisms by which mutant FUS becomes toxic to n...

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Veröffentlicht in:	ACTA NEUROPATHOLOGICA 2024-06, Vol.147 (1)
Hauptverfasser:	Tziortzouda, Paraskevi, Steyaert, Jolien, Scheveneels, Wendy, Sicart, Adria, Dittlau, Katarina Stoklund, Correia, Adriana Margarida Barbosa, Burg, Thibaut, Pal, Arun, Hermann, Andreas, Van Damme, Philip, Moens, Thomas G, Van Den Bosch, Ludo
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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