Higher COVID-19 pneumonia risk associated with anti-IFN-α than with anti-IFN-ω auto-Abs in children

We found that 19 (10.4%) of 183 unvaccinated children hospitalized for COVID-19 pneumonia had autoantibodies (auto-Abs) neutralizing type I IFNs (IFN-α2 in 10 patients: IFN-α2 only in three, IFN-α2 plus IFN-ω in five, and IFN-α2, IFN-ω plus IFN-β in two; IFN-ω only in nine patients). Seven children...

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Veröffentlicht in:	JOURNAL OF EXPERIMENTAL MEDICINE 2024-01, Vol.221 (2)
Hauptverfasser:	Bastard, Paul, Gervais, Adrian, Taniguchi, Maki, Saare, Liisa, Sarekannu, Karita, Le Voyer, Tom, Philippot, Quentin, Rosain, Jeremie, Bizien, Lucy, Asano, Takaki, Garcia-Prat, Marina, Parra-Martinez, Alba, Migaud, Melanie, Tsumura, Miyuki, Conti, Francesca, Belot, Alexandre, Riviere, Jacques G, Morio, Tomohiro, Tanaka, Junko, Javouhey, Etienne, Haerynck, Filomeen, Duvlis, Sotirija, Ozcelik, Tayfun, Keles, Sevgi, Tandjaoui-Lambiotte, Yacine, Escoda, Simon, Husain, Maya, Pan-Hammarstrom, Qiang, Hammarstrom, Lennart, Ahlijah, Gloria, Haidar, Anthony Abi, Soudee, Camille, Arseguel, Vincent, Abolhassani, Hassan, Sahanic, Sabina, Tancevski, Ivan, Nukui, Yoko, Hayakawa, Seiichi, Chrousos, George P, Michos, Athanasios, Tatsi, Elizabeth-Barbara, Filippatos, Filippos, Rodriguez-Palmero, Agusti, Troya, Jesus, Tipu, Imran, Meyts, Isabelle, Roussel, Lucie, Ostrowski, Sisse Rye, Schidlowski, Laire, Prando, Carolina, Condino-Neto, Antonio, Cheikh, Nathalie, Bousfiha, Ahmed A, El Bakkouri, Jalila, Peterson, Part, Pujol, Aurora, Levy, Romain, Quartier, Pierre, Vinh, Donald C, Boisson, Bertrand, Beziat, Vivien, Zhang, Shen-Ying, Borghesi, Alessandro, Pession, Andrea, Andreakos, Evangelos, Marr, Nico, Mentis, Alexios-Fotios A, Mogensen, Trine H, Rodriguez-Gallego, Carlos, Soler-Palacin, Pere, Colobran, Roger, Tillmann, Vallo, Neven, Benedicte, Trouillet-Assant, Sophie, Brodin, Petter, Abel, Laurent, Jouanguy, Emmanuelle, Zhang, Qian, Martinon-Torres, Federico, Salas, Antonio, Gomez-Carballa, Alberto, Gonzalez-Granado, Luis I, Kisand, Kai, Okada, Satoshi, Puel, Anne, Cobat, Aurelie, Casanova, Jean-Laurent
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Sprache:	eng
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