Higher COVID-19 pneumonia risk associated with anti-IFN-α than with anti-IFN-ω auto-Abs in children
We found that 19 (10.4%) of 183 unvaccinated children hospitalized for COVID-19 pneumonia had autoantibodies (auto-Abs) neutralizing type I IFNs (IFN-α2 in 10 patients: IFN-α2 only in three, IFN-α2 plus IFN-ω in five, and IFN-α2, IFN-ω plus IFN-β in two; IFN-ω only in nine patients). Seven children...
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| Veröffentlicht in: | JOURNAL OF EXPERIMENTAL MEDICINE 2024-01, Vol.221 (2) |
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| creator | Bastard, Paul Gervais, Adrian Taniguchi, Maki Saare, Liisa Sarekannu, Karita Le Voyer, Tom Philippot, Quentin Rosain, Jeremie Bizien, Lucy Asano, Takaki Garcia-Prat, Marina Parra-Martinez, Alba Migaud, Melanie Tsumura, Miyuki Conti, Francesca Belot, Alexandre Riviere, Jacques G Morio, Tomohiro Tanaka, Junko Javouhey, Etienne Haerynck, Filomeen Duvlis, Sotirija Ozcelik, Tayfun Keles, Sevgi Tandjaoui-Lambiotte, Yacine Escoda, Simon Husain, Maya Pan-Hammarstrom, Qiang Hammarstrom, Lennart Ahlijah, Gloria Haidar, Anthony Abi Soudee, Camille Arseguel, Vincent Abolhassani, Hassan Sahanic, Sabina Tancevski, Ivan Nukui, Yoko Hayakawa, Seiichi Chrousos, George P Michos, Athanasios Tatsi, Elizabeth-Barbara Filippatos, Filippos Rodriguez-Palmero, Agusti Troya, Jesus Tipu, Imran Meyts, Isabelle Roussel, Lucie Ostrowski, Sisse Rye Schidlowski, Laire Prando, Carolina Condino-Neto, Antonio Cheikh, Nathalie Bousfiha, Ahmed A El Bakkouri, Jalila Peterson, Part Pujol, Aurora Levy, Romain Quartier, Pierre Vinh, Donald C Boisson, Bertrand Beziat, Vivien Zhang, Shen-Ying Borghesi, Alessandro Pession, Andrea Andreakos, Evangelos Marr, Nico Mentis, Alexios-Fotios A Mogensen, Trine H Rodriguez-Gallego, Carlos Soler-Palacin, Pere Colobran, Roger Tillmann, Vallo Neven, Benedicte Trouillet-Assant, Sophie Brodin, Petter Abel, Laurent Jouanguy, Emmanuelle Zhang, Qian Martinon-Torres, Federico Salas, Antonio Gomez-Carballa, Alberto Gonzalez-Granado, Luis I Kisand, Kai Okada, Satoshi Puel, Anne Cobat, Aurelie Casanova, Jean-Laurent |
| description | We found that 19 (10.4%) of 183 unvaccinated children hospitalized for COVID-19 pneumonia had autoantibodies (auto-Abs) neutralizing type I IFNs (IFN-α2 in 10 patients: IFN-α2 only in three, IFN-α2 plus IFN-ω in five, and IFN-α2, IFN-ω plus IFN-β in two; IFN-ω only in nine patients). Seven children (3.8%) had Abs neutralizing at least 10 ng/ml of one IFN, whereas the other 12 (6.6%) had Abs neutralizing only 100 pg/ml. The auto-Abs neutralized both unglycosylated and glycosylated IFNs. We also detected auto-Abs neutralizing 100 pg/ml IFN-α2 in 4 of 2,267 uninfected children (0.2%) and auto-Abs neutralizing IFN-ω in 45 children (2%). The odds ratios (ORs) for life-threatening COVID-19 pneumonia were, therefore, higher for auto-Abs neutralizing IFN-α2 only (OR [95% CI] = 67.6 [5.7-9,196.6]) than for auto-Abs neutralizing IFN-ω only (OR [95% CI] = 2.6 [1.2-5.3]). ORs were also higher for auto-Abs neutralizing high concentrations (OR [95% CI] = 12.9 [4.6-35.9]) than for those neutralizing low concentrations (OR [95% CI] = 5.5 [3.1-9.6]) of IFN-ω and/or IFN-α2. |
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Seven children (3.8%) had Abs neutralizing at least 10 ng/ml of one IFN, whereas the other 12 (6.6%) had Abs neutralizing only 100 pg/ml. The auto-Abs neutralized both unglycosylated and glycosylated IFNs. We also detected auto-Abs neutralizing 100 pg/ml IFN-α2 in 4 of 2,267 uninfected children (0.2%) and auto-Abs neutralizing IFN-ω in 45 children (2%). The odds ratios (ORs) for life-threatening COVID-19 pneumonia were, therefore, higher for auto-Abs neutralizing IFN-α2 only (OR [95% CI] = 67.6 [5.7-9,196.6]) than for auto-Abs neutralizing IFN-ω only (OR [95% CI] = 2.6 [1.2-5.3]). ORs were also higher for auto-Abs neutralizing high concentrations (OR [95% CI] = 12.9 [4.6-35.9]) than for those neutralizing low concentrations (OR [95% CI] = 5.5 [3.1-9.6]) of IFN-ω and/or IFN-α2.</description><identifier>ISSN: 0022-1007</identifier><language>eng</language><publisher>ROCKEFELLER UNIV PRESS</publisher><ispartof>JOURNAL OF EXPERIMENTAL MEDICINE, 2024-01, Vol.221 (2)</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,315,776,780,27839</link.rule.ids></links><search><creatorcontrib>Bastard, Paul</creatorcontrib><creatorcontrib>Gervais, Adrian</creatorcontrib><creatorcontrib>Taniguchi, Maki</creatorcontrib><creatorcontrib>Saare, Liisa</creatorcontrib><creatorcontrib>Sarekannu, Karita</creatorcontrib><creatorcontrib>Le Voyer, 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Anne</creatorcontrib><creatorcontrib>Cobat, Aurelie</creatorcontrib><creatorcontrib>Casanova, Jean-Laurent</creatorcontrib><title>Higher COVID-19 pneumonia risk associated with anti-IFN-α than with anti-IFN-ω auto-Abs in children</title><title>JOURNAL OF EXPERIMENTAL MEDICINE</title><description>We found that 19 (10.4%) of 183 unvaccinated children hospitalized for COVID-19 pneumonia had autoantibodies (auto-Abs) neutralizing type I IFNs (IFN-α2 in 10 patients: IFN-α2 only in three, IFN-α2 plus IFN-ω in five, and IFN-α2, IFN-ω plus IFN-β in two; IFN-ω only in nine patients). Seven children (3.8%) had Abs neutralizing at least 10 ng/ml of one IFN, whereas the other 12 (6.6%) had Abs neutralizing only 100 pg/ml. The auto-Abs neutralized both unglycosylated and glycosylated IFNs. We also detected auto-Abs neutralizing 100 pg/ml IFN-α2 in 4 of 2,267 uninfected children (0.2%) and auto-Abs neutralizing IFN-ω in 45 children (2%). The odds ratios (ORs) for life-threatening COVID-19 pneumonia were, therefore, higher for auto-Abs neutralizing IFN-α2 only (OR [95% CI] = 67.6 [5.7-9,196.6]) than for auto-Abs neutralizing IFN-ω only (OR [95% CI] = 2.6 [1.2-5.3]). ORs were also higher for auto-Abs neutralizing high concentrations (OR [95% CI] = 12.9 [4.6-35.9]) than for those neutralizing low concentrations (OR [95% CI] = 5.5 [3.1-9.6]) of IFN-ω and/or IFN-α2.</description><issn>0022-1007</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>FZOIL</sourceid><recordid>eNqVjLsKwjAUQDMo-PyHOwuR26StOIoPdNFFXENsrzZaU2lS9Rf8HH9Ef8nFyUmnA4fDqbEmohA8QBw0WMu5A2IQhlHcZDQ3-4xKGK82iwkPhnC2VJ0KazSUxh1BO1ckRntK4Wp8Btp6wxezJX8-wGfaftnXHXTlCz7aOjAWkszkaUm2w-o7nTvqfthmvdl0PZ7zY5VTdSGrUnfWCSmBKkJUgRiGQg2kjGUk26z_c6z8zcu_7m__EVYi</recordid><startdate>20240104</startdate><enddate>20240104</enddate><creator>Bastard, Paul</creator><creator>Gervais, Adrian</creator><creator>Taniguchi, Maki</creator><creator>Saare, Liisa</creator><creator>Sarekannu, Karita</creator><creator>Le Voyer, Tom</creator><creator>Philippot, Quentin</creator><creator>Rosain, Jeremie</creator><creator>Bizien, 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Jean-Laurent</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-kuleuven_dspace_20_500_12942_7336353</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bastard, Paul</creatorcontrib><creatorcontrib>Gervais, Adrian</creatorcontrib><creatorcontrib>Taniguchi, Maki</creatorcontrib><creatorcontrib>Saare, Liisa</creatorcontrib><creatorcontrib>Sarekannu, Karita</creatorcontrib><creatorcontrib>Le Voyer, Tom</creatorcontrib><creatorcontrib>Philippot, Quentin</creatorcontrib><creatorcontrib>Rosain, Jeremie</creatorcontrib><creatorcontrib>Bizien, Lucy</creatorcontrib><creatorcontrib>Asano, Takaki</creatorcontrib><creatorcontrib>Garcia-Prat, Marina</creatorcontrib><creatorcontrib>Parra-Martinez, Alba</creatorcontrib><creatorcontrib>Migaud, Melanie</creatorcontrib><creatorcontrib>Tsumura, Miyuki</creatorcontrib><creatorcontrib>Conti, Francesca</creatorcontrib><creatorcontrib>Belot, Alexandre</creatorcontrib><creatorcontrib>Riviere, Jacques G</creatorcontrib><creatorcontrib>Morio, Tomohiro</creatorcontrib><creatorcontrib>Tanaka, Junko</creatorcontrib><creatorcontrib>Javouhey, Etienne</creatorcontrib><creatorcontrib>Haerynck, Filomeen</creatorcontrib><creatorcontrib>Duvlis, Sotirija</creatorcontrib><creatorcontrib>Ozcelik, Tayfun</creatorcontrib><creatorcontrib>Keles, Sevgi</creatorcontrib><creatorcontrib>Tandjaoui-Lambiotte, Yacine</creatorcontrib><creatorcontrib>Escoda, Simon</creatorcontrib><creatorcontrib>Husain, Maya</creatorcontrib><creatorcontrib>Pan-Hammarstrom, Qiang</creatorcontrib><creatorcontrib>Hammarstrom, Lennart</creatorcontrib><creatorcontrib>Ahlijah, Gloria</creatorcontrib><creatorcontrib>Haidar, Anthony Abi</creatorcontrib><creatorcontrib>Soudee, Camille</creatorcontrib><creatorcontrib>Arseguel, Vincent</creatorcontrib><creatorcontrib>Abolhassani, Hassan</creatorcontrib><creatorcontrib>Sahanic, Sabina</creatorcontrib><creatorcontrib>Tancevski, Ivan</creatorcontrib><creatorcontrib>Nukui, Yoko</creatorcontrib><creatorcontrib>Hayakawa, Seiichi</creatorcontrib><creatorcontrib>Chrousos, George P</creatorcontrib><creatorcontrib>Michos, Athanasios</creatorcontrib><creatorcontrib>Tatsi, Elizabeth-Barbara</creatorcontrib><creatorcontrib>Filippatos, Filippos</creatorcontrib><creatorcontrib>Rodriguez-Palmero, Agusti</creatorcontrib><creatorcontrib>Troya, Jesus</creatorcontrib><creatorcontrib>Tipu, Imran</creatorcontrib><creatorcontrib>Meyts, Isabelle</creatorcontrib><creatorcontrib>Roussel, Lucie</creatorcontrib><creatorcontrib>Ostrowski, Sisse Rye</creatorcontrib><creatorcontrib>Schidlowski, Laire</creatorcontrib><creatorcontrib>Prando, Carolina</creatorcontrib><creatorcontrib>Condino-Neto, Antonio</creatorcontrib><creatorcontrib>Cheikh, Nathalie</creatorcontrib><creatorcontrib>Bousfiha, Ahmed A</creatorcontrib><creatorcontrib>El Bakkouri, Jalila</creatorcontrib><creatorcontrib>Peterson, Part</creatorcontrib><creatorcontrib>Pujol, Aurora</creatorcontrib><creatorcontrib>Levy, Romain</creatorcontrib><creatorcontrib>Quartier, Pierre</creatorcontrib><creatorcontrib>Vinh, Donald C</creatorcontrib><creatorcontrib>Boisson, Bertrand</creatorcontrib><creatorcontrib>Beziat, Vivien</creatorcontrib><creatorcontrib>Zhang, Shen-Ying</creatorcontrib><creatorcontrib>Borghesi, Alessandro</creatorcontrib><creatorcontrib>Pession, Andrea</creatorcontrib><creatorcontrib>Andreakos, Evangelos</creatorcontrib><creatorcontrib>Marr, Nico</creatorcontrib><creatorcontrib>Mentis, Alexios-Fotios A</creatorcontrib><creatorcontrib>Mogensen, Trine H</creatorcontrib><creatorcontrib>Rodriguez-Gallego, Carlos</creatorcontrib><creatorcontrib>Soler-Palacin, Pere</creatorcontrib><creatorcontrib>Colobran, Roger</creatorcontrib><creatorcontrib>Tillmann, Vallo</creatorcontrib><creatorcontrib>Neven, Benedicte</creatorcontrib><creatorcontrib>Trouillet-Assant, Sophie</creatorcontrib><creatorcontrib>Brodin, Petter</creatorcontrib><creatorcontrib>Abel, Laurent</creatorcontrib><creatorcontrib>Jouanguy, Emmanuelle</creatorcontrib><creatorcontrib>Zhang, Qian</creatorcontrib><creatorcontrib>Martinon-Torres, Federico</creatorcontrib><creatorcontrib>Salas, Antonio</creatorcontrib><creatorcontrib>Gomez-Carballa, Alberto</creatorcontrib><creatorcontrib>Gonzalez-Granado, Luis I</creatorcontrib><creatorcontrib>Kisand, Kai</creatorcontrib><creatorcontrib>Okada, Satoshi</creatorcontrib><creatorcontrib>Puel, Anne</creatorcontrib><creatorcontrib>Cobat, Aurelie</creatorcontrib><creatorcontrib>Casanova, Jean-Laurent</creatorcontrib><collection>Lirias (KU Leuven Association)</collection><jtitle>JOURNAL OF EXPERIMENTAL MEDICINE</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bastard, Paul</au><au>Gervais, Adrian</au><au>Taniguchi, Maki</au><au>Saare, Liisa</au><au>Sarekannu, Karita</au><au>Le Voyer, Tom</au><au>Philippot, Quentin</au><au>Rosain, Jeremie</au><au>Bizien, Lucy</au><au>Asano, Takaki</au><au>Garcia-Prat, Marina</au><au>Parra-Martinez, Alba</au><au>Migaud, Melanie</au><au>Tsumura, Miyuki</au><au>Conti, Francesca</au><au>Belot, Alexandre</au><au>Riviere, Jacques G</au><au>Morio, Tomohiro</au><au>Tanaka, Junko</au><au>Javouhey, Etienne</au><au>Haerynck, Filomeen</au><au>Duvlis, Sotirija</au><au>Ozcelik, Tayfun</au><au>Keles, Sevgi</au><au>Tandjaoui-Lambiotte, Yacine</au><au>Escoda, Simon</au><au>Husain, Maya</au><au>Pan-Hammarstrom, Qiang</au><au>Hammarstrom, Lennart</au><au>Ahlijah, Gloria</au><au>Haidar, Anthony Abi</au><au>Soudee, Camille</au><au>Arseguel, Vincent</au><au>Abolhassani, Hassan</au><au>Sahanic, Sabina</au><au>Tancevski, Ivan</au><au>Nukui, Yoko</au><au>Hayakawa, Seiichi</au><au>Chrousos, George P</au><au>Michos, Athanasios</au><au>Tatsi, Elizabeth-Barbara</au><au>Filippatos, Filippos</au><au>Rodriguez-Palmero, Agusti</au><au>Troya, Jesus</au><au>Tipu, Imran</au><au>Meyts, Isabelle</au><au>Roussel, Lucie</au><au>Ostrowski, Sisse Rye</au><au>Schidlowski, Laire</au><au>Prando, Carolina</au><au>Condino-Neto, Antonio</au><au>Cheikh, Nathalie</au><au>Bousfiha, Ahmed A</au><au>El Bakkouri, Jalila</au><au>Peterson, Part</au><au>Pujol, Aurora</au><au>Levy, Romain</au><au>Quartier, Pierre</au><au>Vinh, Donald C</au><au>Boisson, Bertrand</au><au>Beziat, Vivien</au><au>Zhang, Shen-Ying</au><au>Borghesi, Alessandro</au><au>Pession, Andrea</au><au>Andreakos, Evangelos</au><au>Marr, Nico</au><au>Mentis, Alexios-Fotios A</au><au>Mogensen, Trine H</au><au>Rodriguez-Gallego, Carlos</au><au>Soler-Palacin, Pere</au><au>Colobran, Roger</au><au>Tillmann, Vallo</au><au>Neven, Benedicte</au><au>Trouillet-Assant, Sophie</au><au>Brodin, Petter</au><au>Abel, Laurent</au><au>Jouanguy, Emmanuelle</au><au>Zhang, Qian</au><au>Martinon-Torres, Federico</au><au>Salas, Antonio</au><au>Gomez-Carballa, Alberto</au><au>Gonzalez-Granado, Luis I</au><au>Kisand, Kai</au><au>Okada, Satoshi</au><au>Puel, Anne</au><au>Cobat, Aurelie</au><au>Casanova, Jean-Laurent</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Higher COVID-19 pneumonia risk associated with anti-IFN-α than with anti-IFN-ω auto-Abs in children</atitle><jtitle>JOURNAL OF EXPERIMENTAL MEDICINE</jtitle><date>2024-01-04</date><risdate>2024</risdate><volume>221</volume><issue>2</issue><issn>0022-1007</issn><abstract>We found that 19 (10.4%) of 183 unvaccinated children hospitalized for COVID-19 pneumonia had autoantibodies (auto-Abs) neutralizing type I IFNs (IFN-α2 in 10 patients: IFN-α2 only in three, IFN-α2 plus IFN-ω in five, and IFN-α2, IFN-ω plus IFN-β in two; IFN-ω only in nine patients). Seven children (3.8%) had Abs neutralizing at least 10 ng/ml of one IFN, whereas the other 12 (6.6%) had Abs neutralizing only 100 pg/ml. The auto-Abs neutralized both unglycosylated and glycosylated IFNs. We also detected auto-Abs neutralizing 100 pg/ml IFN-α2 in 4 of 2,267 uninfected children (0.2%) and auto-Abs neutralizing IFN-ω in 45 children (2%). The odds ratios (ORs) for life-threatening COVID-19 pneumonia were, therefore, higher for auto-Abs neutralizing IFN-α2 only (OR [95% CI] = 67.6 [5.7-9,196.6]) than for auto-Abs neutralizing IFN-ω only (OR [95% CI] = 2.6 [1.2-5.3]). ORs were also higher for auto-Abs neutralizing high concentrations (OR [95% CI] = 12.9 [4.6-35.9]) than for those neutralizing low concentrations (OR [95% CI] = 5.5 [3.1-9.6]) of IFN-ω and/or IFN-α2.</abstract><pub>ROCKEFELLER UNIV PRESS</pub><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-1007 |
| ispartof | JOURNAL OF EXPERIMENTAL MEDICINE, 2024-01, Vol.221 (2) |
| issn | 0022-1007 |
| language | eng |
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| source | Lirias (KU Leuven Association); EZB-FREE-00999 freely available EZB journals |
| title | Higher COVID-19 pneumonia risk associated with anti-IFN-α than with anti-IFN-ω auto-Abs in children |
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