Effect of a mobile app chatbot and an interactive small-group webinar on COVID-19 vaccine intention and confidence in Japan: a randomised controlled trial

Effect of a mobile app chatbot and an interactive small-group webinar on COVID-19 vaccine intention and confidence in Japan: a randomised controlled trial

INTRODUCTION: We investigated the effect of social media-based interventions on COVID-19 vaccine intention (VI) and confidence in Japan. METHODS: We conducted a three-arm randomised controlled trial between 5 November 2021 and 9 January 2022 during a low incidence (

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Veröffentlicht in:BMJ GLOBAL HEALTH 2023-05, Vol.8 (5)
Hauptverfasser: Kobayashi, Takaaki, Tomoi, Hana, Nishina, Yuka, Harada, Ko, Tanaka, Kyuto, Sasaki, Shugo, Inaba, Kanako, Mitaka, Hayato, Takahashi, Hiromizu, Passanante, Aly, Lau, Eric H.Y, Naito, Toshio, Larson, Heidi, Wu, Joseph, Lin, Leesa, Yamada, Yuji
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container_title BMJ GLOBAL HEALTH
container_volume 8
creator Kobayashi, Takaaki
Tomoi, Hana
Nishina, Yuka
Harada, Ko
Tanaka, Kyuto
Sasaki, Shugo
Inaba, Kanako
Mitaka, Hayato
Takahashi, Hiromizu
Passanante, Aly
Lau, Eric H.Y
Naito, Toshio
Larson, Heidi
Wu, Joseph
Lin, Leesa
Yamada, Yuji
description INTRODUCTION: We investigated the effect of social media-based interventions on COVID-19 vaccine intention (VI) and confidence in Japan. METHODS: We conducted a three-arm randomised controlled trial between 5 November 2021 and 9 January 2022 during a low incidence (
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METHODS: We conducted a three-arm randomised controlled trial between 5 November 2021 and 9 January 2022 during a low incidence (&lt;1000/day) of COVID-19 in Japan in the midst of the second and the third waves. Japanese citizens aged ≥20 who had not received any COVID-19 vaccine and did not intend to be vaccinated were randomly assigned to one of the following three groups: (1) a control group, (2) a group using a mobile app chatbot providing information on COVID-19 vaccines and (3) a group using interactive webinars with health professionals. VI and predefined Vaccine Confidence Index (VCI) measuring confidence in the importance, safety and effectiveness were compared before and after the interventions under intention-to-treat principle. Logistic regression models were used to investigate the effect of each intervention on postintervention VI and changes of VCI compared with control. RESULTS: Among 386 participants in each group, 359 (93.0%), 231 (59.8%) and 207 (53.6%) completed the postsurvey for the control, chatbot and webinar groups, respectively. The average duration between the intervention and the postsurvey was 32 days in chatbot group and 27 days in webinar group. VI increased from 0% to 18.5% (95% CI 14.5%, 22.5%) in control group, 15.4% (95% CI 10.8%, 20.1%) in chatbot group and 19.7% (95% CI 14.5%, 24.9%) in webinar group without significant difference (OR for improvement=0.8 (95% CI 0.5, 1.3), p=0.33 between chatbot and control, OR=1.1 (95% CI 0.7, 1.6), p=0.73 between webinar and control). VCI change tended to be larger in chatbot group compared with control group without significant difference (3.3% vs -2.5% in importance, OR for improvement=1.3 (95% CI 0.9, 2.0), p=0.18; 2.5% vs 1.9% in safety, OR=1.1 (95% CI 0.7, 1.9), p=0.62; -2.4% vs -7.6% in effectiveness, OR=1.4 (95% CI 0.9, 2.1), p=0.09). Improvement in VCI was larger in webinar group compared with control group for importance (7.8% vs -2.5%, OR=1.8 (95% CI 1.2, 2.8), p&lt;0.01), effectiveness (6.4% vs -7.6%, OR=2.2 (95% CI 1.4, 3.4), p&lt;0.01) and safety (6.0% vs 1.9%, OR=1.6 (95% CI 1.0, 2.6), p=0.08). CONCLUSION: This study demonstrated that neither the chatbot nor the webinar changed VI importantly compared with control. Interactive webinars could be an effective tool to change vaccine confidence. Further study is needed to identify risk factors associated with decreased vaccine confidence and investigate what intervention can increase VI and vaccine confidence for COVID-19 vaccines. TRIAL REGISTRATION NUMBER: UMIN000045747.</description><identifier>ISSN: 2059-7908</identifier><identifier>EISSN: 2059-7908</identifier><language>eng</language><publisher>BMJ PUBLISHING GROUP</publisher><ispartof>BMJ GLOBAL HEALTH, 2023-05, Vol.8 (5)</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,315,777,781,27841</link.rule.ids></links><search><creatorcontrib>Kobayashi, Takaaki</creatorcontrib><creatorcontrib>Tomoi, Hana</creatorcontrib><creatorcontrib>Nishina, Yuka</creatorcontrib><creatorcontrib>Harada, Ko</creatorcontrib><creatorcontrib>Tanaka, Kyuto</creatorcontrib><creatorcontrib>Sasaki, Shugo</creatorcontrib><creatorcontrib>Inaba, Kanako</creatorcontrib><creatorcontrib>Mitaka, Hayato</creatorcontrib><creatorcontrib>Takahashi, Hiromizu</creatorcontrib><creatorcontrib>Passanante, Aly</creatorcontrib><creatorcontrib>Lau, Eric H.Y</creatorcontrib><creatorcontrib>Naito, Toshio</creatorcontrib><creatorcontrib>Larson, Heidi</creatorcontrib><creatorcontrib>Wu, Joseph</creatorcontrib><creatorcontrib>Lin, Leesa</creatorcontrib><creatorcontrib>Yamada, Yuji</creatorcontrib><title>Effect of a mobile app chatbot and an interactive small-group webinar on COVID-19 vaccine intention and confidence in Japan: a randomised controlled trial</title><title>BMJ GLOBAL HEALTH</title><description>INTRODUCTION: We investigated the effect of social media-based interventions on COVID-19 vaccine intention (VI) and confidence in Japan. METHODS: We conducted a three-arm randomised controlled trial between 5 November 2021 and 9 January 2022 during a low incidence (&lt;1000/day) of COVID-19 in Japan in the midst of the second and the third waves. Japanese citizens aged ≥20 who had not received any COVID-19 vaccine and did not intend to be vaccinated were randomly assigned to one of the following three groups: (1) a control group, (2) a group using a mobile app chatbot providing information on COVID-19 vaccines and (3) a group using interactive webinars with health professionals. VI and predefined Vaccine Confidence Index (VCI) measuring confidence in the importance, safety and effectiveness were compared before and after the interventions under intention-to-treat principle. Logistic regression models were used to investigate the effect of each intervention on postintervention VI and changes of VCI compared with control. RESULTS: Among 386 participants in each group, 359 (93.0%), 231 (59.8%) and 207 (53.6%) completed the postsurvey for the control, chatbot and webinar groups, respectively. The average duration between the intervention and the postsurvey was 32 days in chatbot group and 27 days in webinar group. VI increased from 0% to 18.5% (95% CI 14.5%, 22.5%) in control group, 15.4% (95% CI 10.8%, 20.1%) in chatbot group and 19.7% (95% CI 14.5%, 24.9%) in webinar group without significant difference (OR for improvement=0.8 (95% CI 0.5, 1.3), p=0.33 between chatbot and control, OR=1.1 (95% CI 0.7, 1.6), p=0.73 between webinar and control). VCI change tended to be larger in chatbot group compared with control group without significant difference (3.3% vs -2.5% in importance, OR for improvement=1.3 (95% CI 0.9, 2.0), p=0.18; 2.5% vs 1.9% in safety, OR=1.1 (95% CI 0.7, 1.9), p=0.62; -2.4% vs -7.6% in effectiveness, OR=1.4 (95% CI 0.9, 2.1), p=0.09). Improvement in VCI was larger in webinar group compared with control group for importance (7.8% vs -2.5%, OR=1.8 (95% CI 1.2, 2.8), p&lt;0.01), effectiveness (6.4% vs -7.6%, OR=2.2 (95% CI 1.4, 3.4), p&lt;0.01) and safety (6.0% vs 1.9%, OR=1.6 (95% CI 1.0, 2.6), p=0.08). CONCLUSION: This study demonstrated that neither the chatbot nor the webinar changed VI importantly compared with control. Interactive webinars could be an effective tool to change vaccine confidence. Further study is needed to identify risk factors associated with decreased vaccine confidence and investigate what intervention can increase VI and vaccine confidence for COVID-19 vaccines. TRIAL REGISTRATION NUMBER: UMIN000045747.</description><issn>2059-7908</issn><issn>2059-7908</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>FZOIL</sourceid><recordid>eNqVjc9OwzAMhyMEEhPsHXxGKkr_bKVcxxBw4YK4Rm7qbIE0iZK08Cw8LdnEgSMcbP-k77N9whYVX3VF2_Gb01_5nC1jfOOcl21ufL1gX1ulSCZwChBG12tDgN6D3GPqXQK0Qy7QNlFAmfRMEEc0ptgFN3n4oF5bDOAsbJ5fH--KsoMZpdSWjjs26YwOR6SzSg9k5QHAE3q0t_llyMyNOtLRSMEZk2MKGs0lO1NoIi1_5gW7ut--bB6K98nQNJMVQ_QoSVRcrDgXZdU1lWhrvm6a-p_y9Z9lkT5T_Q2uyWv-</recordid><startdate>202305</startdate><enddate>202305</enddate><creator>Kobayashi, Takaaki</creator><creator>Tomoi, Hana</creator><creator>Nishina, Yuka</creator><creator>Harada, Ko</creator><creator>Tanaka, Kyuto</creator><creator>Sasaki, Shugo</creator><creator>Inaba, Kanako</creator><creator>Mitaka, Hayato</creator><creator>Takahashi, Hiromizu</creator><creator>Passanante, Aly</creator><creator>Lau, Eric H.Y</creator><creator>Naito, Toshio</creator><creator>Larson, Heidi</creator><creator>Wu, Joseph</creator><creator>Lin, Leesa</creator><creator>Yamada, Yuji</creator><general>BMJ PUBLISHING GROUP</general><scope>FZOIL</scope></search><sort><creationdate>202305</creationdate><title>Effect of a mobile app chatbot and an interactive small-group webinar on COVID-19 vaccine intention and confidence in Japan: a randomised controlled trial</title><author>Kobayashi, Takaaki ; Tomoi, Hana ; Nishina, Yuka ; Harada, Ko ; Tanaka, Kyuto ; Sasaki, Shugo ; Inaba, Kanako ; Mitaka, Hayato ; Takahashi, Hiromizu ; Passanante, Aly ; Lau, Eric H.Y ; Naito, Toshio ; Larson, Heidi ; Wu, Joseph ; Lin, Leesa ; Yamada, Yuji</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-kuleuven_dspace_20_500_12942_7306443</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kobayashi, Takaaki</creatorcontrib><creatorcontrib>Tomoi, Hana</creatorcontrib><creatorcontrib>Nishina, Yuka</creatorcontrib><creatorcontrib>Harada, Ko</creatorcontrib><creatorcontrib>Tanaka, Kyuto</creatorcontrib><creatorcontrib>Sasaki, Shugo</creatorcontrib><creatorcontrib>Inaba, Kanako</creatorcontrib><creatorcontrib>Mitaka, Hayato</creatorcontrib><creatorcontrib>Takahashi, Hiromizu</creatorcontrib><creatorcontrib>Passanante, Aly</creatorcontrib><creatorcontrib>Lau, Eric H.Y</creatorcontrib><creatorcontrib>Naito, Toshio</creatorcontrib><creatorcontrib>Larson, Heidi</creatorcontrib><creatorcontrib>Wu, Joseph</creatorcontrib><creatorcontrib>Lin, Leesa</creatorcontrib><creatorcontrib>Yamada, Yuji</creatorcontrib><collection>Lirias (KU Leuven Association)</collection><jtitle>BMJ GLOBAL HEALTH</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kobayashi, Takaaki</au><au>Tomoi, Hana</au><au>Nishina, Yuka</au><au>Harada, Ko</au><au>Tanaka, Kyuto</au><au>Sasaki, Shugo</au><au>Inaba, Kanako</au><au>Mitaka, Hayato</au><au>Takahashi, Hiromizu</au><au>Passanante, Aly</au><au>Lau, Eric H.Y</au><au>Naito, Toshio</au><au>Larson, Heidi</au><au>Wu, Joseph</au><au>Lin, Leesa</au><au>Yamada, Yuji</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of a mobile app chatbot and an interactive small-group webinar on COVID-19 vaccine intention and confidence in Japan: a randomised controlled trial</atitle><jtitle>BMJ GLOBAL HEALTH</jtitle><date>2023-05</date><risdate>2023</risdate><volume>8</volume><issue>5</issue><issn>2059-7908</issn><eissn>2059-7908</eissn><abstract>INTRODUCTION: We investigated the effect of social media-based interventions on COVID-19 vaccine intention (VI) and confidence in Japan. METHODS: We conducted a three-arm randomised controlled trial between 5 November 2021 and 9 January 2022 during a low incidence (&lt;1000/day) of COVID-19 in Japan in the midst of the second and the third waves. Japanese citizens aged ≥20 who had not received any COVID-19 vaccine and did not intend to be vaccinated were randomly assigned to one of the following three groups: (1) a control group, (2) a group using a mobile app chatbot providing information on COVID-19 vaccines and (3) a group using interactive webinars with health professionals. VI and predefined Vaccine Confidence Index (VCI) measuring confidence in the importance, safety and effectiveness were compared before and after the interventions under intention-to-treat principle. Logistic regression models were used to investigate the effect of each intervention on postintervention VI and changes of VCI compared with control. RESULTS: Among 386 participants in each group, 359 (93.0%), 231 (59.8%) and 207 (53.6%) completed the postsurvey for the control, chatbot and webinar groups, respectively. The average duration between the intervention and the postsurvey was 32 days in chatbot group and 27 days in webinar group. VI increased from 0% to 18.5% (95% CI 14.5%, 22.5%) in control group, 15.4% (95% CI 10.8%, 20.1%) in chatbot group and 19.7% (95% CI 14.5%, 24.9%) in webinar group without significant difference (OR for improvement=0.8 (95% CI 0.5, 1.3), p=0.33 between chatbot and control, OR=1.1 (95% CI 0.7, 1.6), p=0.73 between webinar and control). VCI change tended to be larger in chatbot group compared with control group without significant difference (3.3% vs -2.5% in importance, OR for improvement=1.3 (95% CI 0.9, 2.0), p=0.18; 2.5% vs 1.9% in safety, OR=1.1 (95% CI 0.7, 1.9), p=0.62; -2.4% vs -7.6% in effectiveness, OR=1.4 (95% CI 0.9, 2.1), p=0.09). Improvement in VCI was larger in webinar group compared with control group for importance (7.8% vs -2.5%, OR=1.8 (95% CI 1.2, 2.8), p&lt;0.01), effectiveness (6.4% vs -7.6%, OR=2.2 (95% CI 1.4, 3.4), p&lt;0.01) and safety (6.0% vs 1.9%, OR=1.6 (95% CI 1.0, 2.6), p=0.08). CONCLUSION: This study demonstrated that neither the chatbot nor the webinar changed VI importantly compared with control. Interactive webinars could be an effective tool to change vaccine confidence. Further study is needed to identify risk factors associated with decreased vaccine confidence and investigate what intervention can increase VI and vaccine confidence for COVID-19 vaccines. TRIAL REGISTRATION NUMBER: UMIN000045747.</abstract><pub>BMJ PUBLISHING GROUP</pub><oa>free_for_read</oa></addata></record>
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title Effect of a mobile app chatbot and an interactive small-group webinar on COVID-19 vaccine intention and confidence in Japan: a randomised controlled trial
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