Assessing the causal role of epigenetic clocks in the development of multiple cancers: a Mendelian randomization study

BACKGROUND: Epigenetic clocks have been associated with cancer risk in several observational studies. Nevertheless, it is unclear whether they play a causal role in cancer risk or if they act as a non-causal biomarker. METHODS: We conducted a two-sample Mendelian randomization (MR) study to examine...

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Veröffentlicht in:	ELIFE 2022-03, Vol.11
Hauptverfasser:	Berstein, Fernanda Morales, McCartney, Daniel L, Lu, Ake T, Tsilidis, Konstantinos K, Bouras, Emmanouil, Haycock, Philip, Burrows, Kimberley, Phipps, Amanda, Buchanan, Daniel D, Cheng, Iona, the PRACTICAL consortium, Martin, Richard M, Smith, George Davey, Relton, Caroline L, Horvath, Steve, Marioni, Riccardo E, Richardson, Tom G, Richmond, Rebecca C
Format:	Artikel
Sprache:	eng
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