Polyketide Synthase-Mediated O-Methyloxime Formation in the Biosynthesis of the Oximidine Anticancer Agents

Bacterial trans-acyltransferase polyketide synthases (trans-AT PKSs) are modular megaenzymes that employ unusual catalytic domains to assemble diverse bioactive natural products. One such PKS is responsible for the biosynthesis of the oximidine anticancer agents, oxime-substituted benzolactone enami...

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Veröffentlicht in:	ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 2023-08, Vol.62 (34)
Hauptverfasser:	Vriens, Eveline, De Ruysscher, Dries, Weir, Angus N.M, Dekimpe, Sofie, Steurs, Gert, Shemy, Ahmed, Persoons, Leentje, Santos, Ana Rita, Williams, Christopher, Daelemans, Dirk, Crump, Matthew P, Voet, Arnout, De Borggraeve, Wim, Lescrinier, Eveline, Masschelein, Joleen
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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