Baseline Characteristics and Risk Profiles of Participants in the ISCHEMIA Randomized Clinical Trial

Baseline Characteristics and Risk Profiles of Participants in the ISCHEMIA Randomized Clinical Trial

IMPORTANCE: It is unknown whether coronary revascularization, when added to optimal medical therapy, improves prognosis in patients with stable ischemic heart disease (SIHD) at increased risk of cardiovascular events owing to moderate or severe ischemia. OBJECTIVE: To describe baseline characteristi...

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Veröffentlicht in:JAMA CARDIOLOGY 2019-03, Vol.4 (3), p.273-286
Hauptverfasser: Hochman, Judith S, Reynolds, Harmony R, Bangalore, Sripal, O'Brien, Sean M, Alexander, Karen P, Senior, Roxy, Boden, William E, Stone, Gregg W, Goodman, Shaun G, Lopes, Renato D, Lopez-Sendon, Jose, White, Harvey D, Maggioni, Aldo P, Shaw, Leslee J, Min, James K, Picard, Michael H, Berman, Daniel S, Chaitman, Bernard R, Mark, Daniel B, Spertus, John A, Cyr, Derek D, Bhargava, Balram, Ruzyllo, Witold, Wander, Gurpreet S, Chernyavskiy, Alexander M, Rosenberg, Yves D, Maron, David J, Mavromatis, Kreton, Miller, Todd, Banerjee, Subhash, Abdul-Nour, Khaled, Stone, Peter H, Jang, James J, Weitz, Steven, Arnold, Suzanne, Shapiro, Michael D, El-Hajjar, Mohammad, McFalls, Edward O, Khouri, Michel Georges, Goldberg, Jonathan L, Goldweit, Richard, Cohen, Ronny A, Winchester, David E, Kronenberg, Marvin, Heitner, John F, Dauber, Ira M, Cannan, Charles, Sudarshan, Sriram, Mehta, Puja K, Hedgepeth, Chester M, Sahul, Zakir, Booth, David, Setty, Sampoornima, Barua, Rajat S, Hage, Fadi, Dajani, Khaled, Arif, Imran, Trejo (Gutierrez), Jorge F, Gemignani, Anthony, Meadows, Judith L, Call, Jason T, Hannan, Joseph, Martin, Edward T, Vorobiof, Gabriel, Moorman, Alec, Kinlay, Scott, Rayos, Glenn, Seedhom, Ashraf, Kumkumian, Gregory, Sedlis, Steven P, Tamis-Holland, Jacqueline E, Saba, Souheil, Badami, Umesh, Marzo, Kevin, Robbins, Inga H, Hamroff, Glenn S, Little, Raymond W, Lui, Charles Y, Hu, Bob, Labovitz, Arthur J, Rodriguez, Fatima, Deedwania, Prakash, Sweeny, Joseph, Spizzieri, Christopher, Hochberg, Claudia P, Salerno, William D, Wyman, Ray, Zarka, Amer, Haldis, Thomas, Kohn, Jeffrey A, Girotra, Saket, Almousalli, Omar, Krishnam, Mayil S, Coram, Rita, Thomas, Sabu, El Shahawy, Mahfouz, Stafford, James, Abernethy, William B, Zurick, Andrew, Meyer, Thomas M
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Sprache:eng
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Zusammenfassung:IMPORTANCE: It is unknown whether coronary revascularization, when added to optimal medical therapy, improves prognosis in patients with stable ischemic heart disease (SIHD) at increased risk of cardiovascular events owing to moderate or severe ischemia. OBJECTIVE: To describe baseline characteristics of participants enrolled and randomized in the International Study of Comparative Health Effectiveness With Medical and Invasive Approaches (ISCHEMIA) trial and to evaluate whether qualification by stress imaging or nonimaging exercise tolerance test (ETT) influenced risk profiles. DESIGN, SETTING, AND PARTICIPANTS: The ISCHEMIA trial recruited patients with SIHD with moderate or severe ischemia on stress testing. Blinded coronary computed tomography angiography was performed in most participants and reviewed by a core laboratory to exclude left main stenosis of at least 50% or no obstructive coronary artery disease (CAD) (
ISSN:2380-6583