Nirogacestat, a γ-Secretase Inhibitor for Desmoid Tumors

BACKGROUND: Desmoid tumors are rare, locally aggressive, highly recurrent soft-tissue tumors without approved treatments. METHODS: We conducted a phase 3, international, double-blind, randomized, placebo-controlled trial of nirogacestat in adults with progressing desmoid tumors according to the Resp...

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Veröffentlicht in:	NEW ENGLAND JOURNAL OF MEDICINE 2023-03, Vol.388 (10), p.898-912
Hauptverfasser:	Gounder, Mrinal, Ratan, Ravin, Alcindor, Thierry, Schoeffski, Patrick, van der Graaf, Winette T, Wilky, Breelyn A, Riedel, Richard F, Lim, Allison, Smith, L. Mary, Moody, Stephanie, Attia, Steven, Chawla, Sant, D'Amato, Gina, Federman, Noah, Merriam, Priscilla, Van Tine, Brian A, Vincenzi, Bruno, Benson, Charlotte, Bui, Nam Quoc, Chugh, Rashmi, Tinoco, Gabriel, Charlson, John, Dileo, Palma, Hartner, Lee, Lapeire, Lore, Mazzeo, Filomena, Palmerini, Emanuela, Reichardt, Peter, Stacchiotti, Silvia, Bailey, Howard H, Burgess, Melissa A, Cote, Gregory M, Davis, Lara E, Deshpande, Hari, Gelderblom, Hans, Grignani, Giovanni, Loggers, Elizabeth, Philip, Tony, Pressey, Joseph G, Kummar, Shivaani, Kasper, Bernd
Format:	Artikel
Sprache:	eng
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