Normal glucose tolerant women with low glycemia during the oral glucose tolerance test have a higher risk to deliver a low birth weight infant
BACKGROUND: Data are limited on pregnancy outcomes of normal glucose tolerant (NGT) women with a low glycemic value measured during the 75g oral glucose tolerance test (OGTT). Our aim was to evaluate maternal characteristics and pregnancy outcomes of NGT women with low glycemia measured at fasting,...
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| Veröffentlicht in: | FRONTIERS IN ENDOCRINOLOGY 2023-06, Vol.14 |
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| creator | Raets, Lore Van Doninck, Lore Van Crombrugge, Paul Moyson, Carolien Verhaeghe, Johan Vandeginste, Sofie Verlaenen, Hilde Vercammen, Chris Maes, Toon Dufraimont, Els Roggen, Nele De Block, Christophe Jacquemyn, Yves Mekahli, Farah De Clippel, Katrien Van den Bruel, Annick Loccufier, Anne Laenen, Annouschka Devlieger, Roland Mathieu, Chantal Benhalima, Katrien |
| description | BACKGROUND: Data are limited on pregnancy outcomes of normal glucose tolerant (NGT) women with a low glycemic value measured during the 75g oral glucose tolerance test (OGTT). Our aim was to evaluate maternal characteristics and pregnancy outcomes of NGT women with low glycemia measured at fasting, 1-hour or 2-hour OGTT. METHODS: The Belgian Diabetes in Pregnancy-N study was a multicentric prospective cohort study with 1841 pregnant women receiving an OGTT to screen for gestational diabetes (GDM). We compared the characteristics and pregnancy outcomes in NGT women according to different groups [(4.4mmol/L)] of lowest glycemia measured during the OGTT. Pregnancy outcomes were adjusted for confounding factors such as body mass index (BMI) and gestational weight gain. RESULTS: Of all NGT women, 10.7% (172) had low glycemia ( |
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| fullrecord | <record><control><sourceid>kuleuven</sourceid><recordid>TN_cdi_kuleuven_dspace_20_500_12942_721423</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>20_500_12942_721423</sourcerecordid><originalsourceid>FETCH-kuleuven_dspace_20_500_12942_7214233</originalsourceid><addsrcrecordid>eNqVjcFugzAMhqOplYZa3sHnSkwhUFrO06addto9SsGQlJBUSYDtJfbMi6oeJu2y-uLf8ufPDyTJq6rMWFGz1a_8SFLvzzRWSfO6Pibk-926UWjo9dRYjxCsRidMgMWOaGBRQYK2S9x_NTgqAe3klOkhSATr_h42MaEPIMWMIECqXqIDp_wQCWhRqznO4uo8KRftC0YmgDJdfLsl605oj-mtb8ju9eXj-S0bJo3TjIa3_iIa5IzyPaU8Z3XJ-IHlJSuKDXn6N8zDZyjusv8A_-tpPA</addsrcrecordid><sourcetype>Institutional Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Normal glucose tolerant women with low glycemia during the oral glucose tolerance test have a higher risk to deliver a low birth weight infant</title><source>Lirias (KU Leuven Association)</source><source>DOAJ Directory of Open Access Journals</source><source>PubMed Central Open Access</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><creator>Raets, Lore ; Van Doninck, Lore ; Van Crombrugge, Paul ; Moyson, Carolien ; Verhaeghe, Johan ; Vandeginste, Sofie ; Verlaenen, Hilde ; Vercammen, Chris ; Maes, Toon ; Dufraimont, Els ; Roggen, Nele ; De Block, Christophe ; Jacquemyn, Yves ; Mekahli, Farah ; De Clippel, Katrien ; Van den Bruel, Annick ; Loccufier, Anne ; Laenen, Annouschka ; Devlieger, Roland ; Mathieu, Chantal ; Benhalima, Katrien</creator><creatorcontrib>Raets, Lore ; Van Doninck, Lore ; Van Crombrugge, Paul ; Moyson, Carolien ; Verhaeghe, Johan ; Vandeginste, Sofie ; Verlaenen, Hilde ; Vercammen, Chris ; Maes, Toon ; Dufraimont, Els ; Roggen, Nele ; De Block, Christophe ; Jacquemyn, Yves ; Mekahli, Farah ; De Clippel, Katrien ; Van den Bruel, Annick ; Loccufier, Anne ; Laenen, Annouschka ; Devlieger, Roland ; Mathieu, Chantal ; Benhalima, Katrien</creatorcontrib><description><![CDATA[BACKGROUND: Data are limited on pregnancy outcomes of normal glucose tolerant (NGT) women with a low glycemic value measured during the 75g oral glucose tolerance test (OGTT). Our aim was to evaluate maternal characteristics and pregnancy outcomes of NGT women with low glycemia measured at fasting, 1-hour or 2-hour OGTT. METHODS: The Belgian Diabetes in Pregnancy-N study was a multicentric prospective cohort study with 1841 pregnant women receiving an OGTT to screen for gestational diabetes (GDM). We compared the characteristics and pregnancy outcomes in NGT women according to different groups [(<3.9mmol/L), (3.9-4.2mmol/L), (4.25-4.4mmol/L) and (>4.4mmol/L)] of lowest glycemia measured during the OGTT. Pregnancy outcomes were adjusted for confounding factors such as body mass index (BMI) and gestational weight gain. RESULTS: Of all NGT women, 10.7% (172) had low glycemia (<3.9 mmol/L) during the OGTT. Women in the lowest glycemic group (<3.9mmol/L) during the OGTT had compared to women in highest glycemic group (>4.4mmol/L, 29.9%, n=482), a better metabolic profile with a lower BMI, less insulin resistance and better beta-cell function. However, women in the lowest glycemic group had more often inadequate gestational weight gain [51.1% (67) vs. 29.5% (123); p<0.001]. Compared to the highest glycemia group, women in the lowest group had more often a birth weight <2.5Kg [adjusted OR 3.41, 95% CI (1.17-9.92); p=0.025]. CONCLUSION: Women with a glycemic value <3.9 mmol/L during the OGTT have a higher risk for a neonate with birth weight < 2.5Kg, which remained significant after adjustment for BMI and gestational weight gain.]]></description><identifier>ISSN: 1664-2392</identifier><identifier>EISSN: 1664-2392</identifier><language>eng</language><publisher>FRONTIERS MEDIA SA</publisher><ispartof>FRONTIERS IN ENDOCRINOLOGY, 2023-06, Vol.14</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,316,782,786,27869</link.rule.ids></links><search><creatorcontrib>Raets, Lore</creatorcontrib><creatorcontrib>Van Doninck, Lore</creatorcontrib><creatorcontrib>Van Crombrugge, Paul</creatorcontrib><creatorcontrib>Moyson, Carolien</creatorcontrib><creatorcontrib>Verhaeghe, Johan</creatorcontrib><creatorcontrib>Vandeginste, Sofie</creatorcontrib><creatorcontrib>Verlaenen, Hilde</creatorcontrib><creatorcontrib>Vercammen, Chris</creatorcontrib><creatorcontrib>Maes, Toon</creatorcontrib><creatorcontrib>Dufraimont, Els</creatorcontrib><creatorcontrib>Roggen, Nele</creatorcontrib><creatorcontrib>De Block, Christophe</creatorcontrib><creatorcontrib>Jacquemyn, Yves</creatorcontrib><creatorcontrib>Mekahli, Farah</creatorcontrib><creatorcontrib>De Clippel, Katrien</creatorcontrib><creatorcontrib>Van den Bruel, Annick</creatorcontrib><creatorcontrib>Loccufier, Anne</creatorcontrib><creatorcontrib>Laenen, Annouschka</creatorcontrib><creatorcontrib>Devlieger, Roland</creatorcontrib><creatorcontrib>Mathieu, Chantal</creatorcontrib><creatorcontrib>Benhalima, Katrien</creatorcontrib><title>Normal glucose tolerant women with low glycemia during the oral glucose tolerance test have a higher risk to deliver a low birth weight infant</title><title>FRONTIERS IN ENDOCRINOLOGY</title><description><![CDATA[BACKGROUND: Data are limited on pregnancy outcomes of normal glucose tolerant (NGT) women with a low glycemic value measured during the 75g oral glucose tolerance test (OGTT). Our aim was to evaluate maternal characteristics and pregnancy outcomes of NGT women with low glycemia measured at fasting, 1-hour or 2-hour OGTT. METHODS: The Belgian Diabetes in Pregnancy-N study was a multicentric prospective cohort study with 1841 pregnant women receiving an OGTT to screen for gestational diabetes (GDM). We compared the characteristics and pregnancy outcomes in NGT women according to different groups [(<3.9mmol/L), (3.9-4.2mmol/L), (4.25-4.4mmol/L) and (>4.4mmol/L)] of lowest glycemia measured during the OGTT. Pregnancy outcomes were adjusted for confounding factors such as body mass index (BMI) and gestational weight gain. RESULTS: Of all NGT women, 10.7% (172) had low glycemia (<3.9 mmol/L) during the OGTT. Women in the lowest glycemic group (<3.9mmol/L) during the OGTT had compared to women in highest glycemic group (>4.4mmol/L, 29.9%, n=482), a better metabolic profile with a lower BMI, less insulin resistance and better beta-cell function. However, women in the lowest glycemic group had more often inadequate gestational weight gain [51.1% (67) vs. 29.5% (123); p<0.001]. Compared to the highest glycemia group, women in the lowest group had more often a birth weight <2.5Kg [adjusted OR 3.41, 95% CI (1.17-9.92); p=0.025]. CONCLUSION: Women with a glycemic value <3.9 mmol/L during the OGTT have a higher risk for a neonate with birth weight < 2.5Kg, which remained significant after adjustment for BMI and gestational weight gain.]]></description><issn>1664-2392</issn><issn>1664-2392</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>FZOIL</sourceid><recordid>eNqVjcFugzAMhqOplYZa3sHnSkwhUFrO06addto9SsGQlJBUSYDtJfbMi6oeJu2y-uLf8ufPDyTJq6rMWFGz1a_8SFLvzzRWSfO6Pibk-926UWjo9dRYjxCsRidMgMWOaGBRQYK2S9x_NTgqAe3klOkhSATr_h42MaEPIMWMIECqXqIDp_wQCWhRqznO4uo8KRftC0YmgDJdfLsl605oj-mtb8ju9eXj-S0bJo3TjIa3_iIa5IzyPaU8Z3XJ-IHlJSuKDXn6N8zDZyjusv8A_-tpPA</recordid><startdate>20230602</startdate><enddate>20230602</enddate><creator>Raets, Lore</creator><creator>Van Doninck, Lore</creator><creator>Van Crombrugge, Paul</creator><creator>Moyson, Carolien</creator><creator>Verhaeghe, Johan</creator><creator>Vandeginste, Sofie</creator><creator>Verlaenen, Hilde</creator><creator>Vercammen, Chris</creator><creator>Maes, Toon</creator><creator>Dufraimont, Els</creator><creator>Roggen, Nele</creator><creator>De Block, Christophe</creator><creator>Jacquemyn, Yves</creator><creator>Mekahli, Farah</creator><creator>De Clippel, Katrien</creator><creator>Van den Bruel, Annick</creator><creator>Loccufier, Anne</creator><creator>Laenen, Annouschka</creator><creator>Devlieger, Roland</creator><creator>Mathieu, Chantal</creator><creator>Benhalima, Katrien</creator><general>FRONTIERS MEDIA SA</general><scope>FZOIL</scope></search><sort><creationdate>20230602</creationdate><title>Normal glucose tolerant women with low glycemia during the oral glucose tolerance test have a higher risk to deliver a low birth weight infant</title><author>Raets, Lore ; Van Doninck, Lore ; Van Crombrugge, Paul ; Moyson, Carolien ; Verhaeghe, Johan ; Vandeginste, Sofie ; Verlaenen, Hilde ; Vercammen, Chris ; Maes, Toon ; Dufraimont, Els ; Roggen, Nele ; De Block, Christophe ; Jacquemyn, Yves ; Mekahli, Farah ; De Clippel, Katrien ; Van den Bruel, Annick ; Loccufier, Anne ; Laenen, Annouschka ; Devlieger, Roland ; Mathieu, Chantal ; Benhalima, Katrien</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-kuleuven_dspace_20_500_12942_7214233</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Raets, Lore</creatorcontrib><creatorcontrib>Van Doninck, Lore</creatorcontrib><creatorcontrib>Van Crombrugge, Paul</creatorcontrib><creatorcontrib>Moyson, Carolien</creatorcontrib><creatorcontrib>Verhaeghe, Johan</creatorcontrib><creatorcontrib>Vandeginste, Sofie</creatorcontrib><creatorcontrib>Verlaenen, Hilde</creatorcontrib><creatorcontrib>Vercammen, Chris</creatorcontrib><creatorcontrib>Maes, Toon</creatorcontrib><creatorcontrib>Dufraimont, Els</creatorcontrib><creatorcontrib>Roggen, Nele</creatorcontrib><creatorcontrib>De Block, Christophe</creatorcontrib><creatorcontrib>Jacquemyn, Yves</creatorcontrib><creatorcontrib>Mekahli, Farah</creatorcontrib><creatorcontrib>De Clippel, Katrien</creatorcontrib><creatorcontrib>Van den Bruel, Annick</creatorcontrib><creatorcontrib>Loccufier, Anne</creatorcontrib><creatorcontrib>Laenen, Annouschka</creatorcontrib><creatorcontrib>Devlieger, Roland</creatorcontrib><creatorcontrib>Mathieu, Chantal</creatorcontrib><creatorcontrib>Benhalima, Katrien</creatorcontrib><collection>Lirias (KU Leuven Association)</collection><jtitle>FRONTIERS IN ENDOCRINOLOGY</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Raets, Lore</au><au>Van Doninck, Lore</au><au>Van Crombrugge, Paul</au><au>Moyson, Carolien</au><au>Verhaeghe, Johan</au><au>Vandeginste, Sofie</au><au>Verlaenen, Hilde</au><au>Vercammen, Chris</au><au>Maes, Toon</au><au>Dufraimont, Els</au><au>Roggen, Nele</au><au>De Block, Christophe</au><au>Jacquemyn, Yves</au><au>Mekahli, Farah</au><au>De Clippel, Katrien</au><au>Van den Bruel, Annick</au><au>Loccufier, Anne</au><au>Laenen, Annouschka</au><au>Devlieger, Roland</au><au>Mathieu, Chantal</au><au>Benhalima, Katrien</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Normal glucose tolerant women with low glycemia during the oral glucose tolerance test have a higher risk to deliver a low birth weight infant</atitle><jtitle>FRONTIERS IN ENDOCRINOLOGY</jtitle><date>2023-06-02</date><risdate>2023</risdate><volume>14</volume><issn>1664-2392</issn><eissn>1664-2392</eissn><abstract><![CDATA[BACKGROUND: Data are limited on pregnancy outcomes of normal glucose tolerant (NGT) women with a low glycemic value measured during the 75g oral glucose tolerance test (OGTT). Our aim was to evaluate maternal characteristics and pregnancy outcomes of NGT women with low glycemia measured at fasting, 1-hour or 2-hour OGTT. METHODS: The Belgian Diabetes in Pregnancy-N study was a multicentric prospective cohort study with 1841 pregnant women receiving an OGTT to screen for gestational diabetes (GDM). We compared the characteristics and pregnancy outcomes in NGT women according to different groups [(<3.9mmol/L), (3.9-4.2mmol/L), (4.25-4.4mmol/L) and (>4.4mmol/L)] of lowest glycemia measured during the OGTT. Pregnancy outcomes were adjusted for confounding factors such as body mass index (BMI) and gestational weight gain. RESULTS: Of all NGT women, 10.7% (172) had low glycemia (<3.9 mmol/L) during the OGTT. Women in the lowest glycemic group (<3.9mmol/L) during the OGTT had compared to women in highest glycemic group (>4.4mmol/L, 29.9%, n=482), a better metabolic profile with a lower BMI, less insulin resistance and better beta-cell function. However, women in the lowest glycemic group had more often inadequate gestational weight gain [51.1% (67) vs. 29.5% (123); p<0.001]. Compared to the highest glycemia group, women in the lowest group had more often a birth weight <2.5Kg [adjusted OR 3.41, 95% CI (1.17-9.92); p=0.025]. CONCLUSION: Women with a glycemic value <3.9 mmol/L during the OGTT have a higher risk for a neonate with birth weight < 2.5Kg, which remained significant after adjustment for BMI and gestational weight gain.]]></abstract><pub>FRONTIERS MEDIA SA</pub><oa>free_for_read</oa></addata></record> |
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| title | Normal glucose tolerant women with low glycemia during the oral glucose tolerance test have a higher risk to deliver a low birth weight infant |
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